Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors
Abstract Although interstitial fluid (ISF) is recognized as an important source of biomarkers, it is difficult and time‐consuming to extract, thus limiting its use in medical diagnostic and clinical settings. An inexpensive and effective technique for accessing ISF could benefit people with various...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-04-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202201763 |
| _version_ | 1797772538192855040 |
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| author | Khaled Mohammed Saifullah Zahra Faraji Rad |
| author_facet | Khaled Mohammed Saifullah Zahra Faraji Rad |
| author_sort | Khaled Mohammed Saifullah |
| collection | DOAJ |
| description | Abstract Although interstitial fluid (ISF) is recognized as an important source of biomarkers, it is difficult and time‐consuming to extract, thus limiting its use in medical diagnostic and clinical settings. An inexpensive and effective technique for accessing ISF could benefit people with various health conditions and offer platforms for on‐device sensing biomarkers. Microneedles (MNs) are minimally invasive devices that have gained extensive interest over recent decades. MNs can address some of the challenges associated with ISF extraction and sensing. Accessing ISF using MNs has the potential to develop advanced, non‐invasive point‐of‐care (POC) microdevices that enable detection or continuous monitoring within the dermal ISF, therefore drastically impacting the healthcare system. This review describes recent studies exploring MN devices for ISF sampling and sensing. Several extraction processes, sampling volume, sampling duration, integration with biosensors, sensing of biomarkers, and subsequent analysis of ISF are discussed in detail. Furthermore, opportunities, conclusions, and future prospects for developing new research in the field are also discussed. |
| first_indexed | 2024-03-12T21:53:19Z |
| format | Article |
| id | doaj.art-9e11721d3b6947ad81a3ed4f2402aa38 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T21:53:19Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-9e11721d3b6947ad81a3ed4f2402aa382023-07-26T01:35:19ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-04-011010n/an/a10.1002/admi.202201763Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based BiosensorsKhaled Mohammed Saifullah0Zahra Faraji Rad1School of Engineering University of Southern Queensland Springfield Queensland 4300 AustraliaSchool of Engineering University of Southern Queensland Springfield Queensland 4300 AustraliaAbstract Although interstitial fluid (ISF) is recognized as an important source of biomarkers, it is difficult and time‐consuming to extract, thus limiting its use in medical diagnostic and clinical settings. An inexpensive and effective technique for accessing ISF could benefit people with various health conditions and offer platforms for on‐device sensing biomarkers. Microneedles (MNs) are minimally invasive devices that have gained extensive interest over recent decades. MNs can address some of the challenges associated with ISF extraction and sensing. Accessing ISF using MNs has the potential to develop advanced, non‐invasive point‐of‐care (POC) microdevices that enable detection or continuous monitoring within the dermal ISF, therefore drastically impacting the healthcare system. This review describes recent studies exploring MN devices for ISF sampling and sensing. Several extraction processes, sampling volume, sampling duration, integration with biosensors, sensing of biomarkers, and subsequent analysis of ISF are discussed in detail. Furthermore, opportunities, conclusions, and future prospects for developing new research in the field are also discussed.https://doi.org/10.1002/admi.202201763biosensingbiosensorsinterstitial fluidmicroneedlespoint‐of‐care diagnostics |
| spellingShingle | Khaled Mohammed Saifullah Zahra Faraji Rad Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors Advanced Materials Interfaces biosensing biosensors interstitial fluid microneedles point‐of‐care diagnostics |
| title | Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors |
| title_full | Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors |
| title_fullStr | Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors |
| title_full_unstemmed | Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors |
| title_short | Sampling Dermal Interstitial Fluid Using Microneedles: A Review of Recent Developments in Sampling Methods and Microneedle‐Based Biosensors |
| title_sort | sampling dermal interstitial fluid using microneedles a review of recent developments in sampling methods and microneedle based biosensors |
| topic | biosensing biosensors interstitial fluid microneedles point‐of‐care diagnostics |
| url | https://doi.org/10.1002/admi.202201763 |
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