Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying
Composites of magnetite nanoparticles encapsulated with polymers attract interest for many applications, especially as theragnostic agents for magnetic hyperthermia, drug delivery, and magnetic resonance imaging. In this work, magnetite nanoparticles were synthesized by coprecipitation and encapsula...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/15/5/1755 |
| _version_ | 1797474589506273280 |
|---|---|
| author | Caio José Perecin Xavier Pierre Marie Gratens Valmir Antônio Chitta Patrícia Leo Adriano Marim de Oliveira Sérgio Akinobu Yoshioka Natália Neto Pereira Cerize |
| author_facet | Caio José Perecin Xavier Pierre Marie Gratens Valmir Antônio Chitta Patrícia Leo Adriano Marim de Oliveira Sérgio Akinobu Yoshioka Natália Neto Pereira Cerize |
| author_sort | Caio José Perecin |
| collection | DOAJ |
| description | Composites of magnetite nanoparticles encapsulated with polymers attract interest for many applications, especially as theragnostic agents for magnetic hyperthermia, drug delivery, and magnetic resonance imaging. In this work, magnetite nanoparticles were synthesized by coprecipitation and encapsulated with different polymers (Eudragit S100, Pluronic F68, Maltodextrin, and surfactants) by nano spray drying technique, which can produce powders of nanoparticles from solutions or suspensions. Transmission and scanning electron microscopy images showed that the bare magnetite nanoparticles have 10.5 nm, and after encapsulation, the particles have approximately 1 μm, with size and shape depending on the material’s composition. The values of magnetic saturation by SQUID magnetometry and mass residues by thermogravimetric analysis were used to characterize the magnetic content in the materials, related to their magnetite/polymer ratios. Zero-field-cooling and field-cooling (ZFC/FC) measurements showed how blocking temperatures of the powders of the composites are lower than that of bare magnetite, possibly due to lower magnetic coupling, being an interesting system to study magnetic interactions of nanoparticles. Furthermore, studies of cytotoxic effect, hydrodynamic size, and heating capacity for hyperthermia (according to the application of an alternate magnetic field) show that these composites could be applied as a theragnostic material for a non-invasive administration such as nasal. |
| first_indexed | 2024-03-09T20:33:14Z |
| format | Article |
| id | doaj.art-9e120c2592de4aeba70fbe03fadccb38 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T20:33:14Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-9e120c2592de4aeba70fbe03fadccb382023-11-23T23:18:20ZengMDPI AGMaterials1996-19442022-02-01155175510.3390/ma15051755Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray DryingCaio José Perecin0Xavier Pierre Marie Gratens1Valmir Antônio Chitta2Patrícia Leo3Adriano Marim de Oliveira4Sérgio Akinobu Yoshioka5Natália Neto Pereira Cerize6São Carlos Institute of Chemistry, University of São Paulo, São Carlos 13566-590, SP, BrazilInstitute of Physics, University of São Paulo, São Paulo 05508-090, SP, BrazilInstitute of Physics, University of São Paulo, São Paulo 05508-090, SP, BrazilBionanomanufacturing Center, Technological Research Institute, São Paulo 05508-070, SP, BrazilBionanomanufacturing Center, Technological Research Institute, São Paulo 05508-070, SP, BrazilSão Carlos Institute of Chemistry, University of São Paulo, São Carlos 13566-590, SP, BrazilBionanomanufacturing Center, Technological Research Institute, São Paulo 05508-070, SP, BrazilComposites of magnetite nanoparticles encapsulated with polymers attract interest for many applications, especially as theragnostic agents for magnetic hyperthermia, drug delivery, and magnetic resonance imaging. In this work, magnetite nanoparticles were synthesized by coprecipitation and encapsulated with different polymers (Eudragit S100, Pluronic F68, Maltodextrin, and surfactants) by nano spray drying technique, which can produce powders of nanoparticles from solutions or suspensions. Transmission and scanning electron microscopy images showed that the bare magnetite nanoparticles have 10.5 nm, and after encapsulation, the particles have approximately 1 μm, with size and shape depending on the material’s composition. The values of magnetic saturation by SQUID magnetometry and mass residues by thermogravimetric analysis were used to characterize the magnetic content in the materials, related to their magnetite/polymer ratios. Zero-field-cooling and field-cooling (ZFC/FC) measurements showed how blocking temperatures of the powders of the composites are lower than that of bare magnetite, possibly due to lower magnetic coupling, being an interesting system to study magnetic interactions of nanoparticles. Furthermore, studies of cytotoxic effect, hydrodynamic size, and heating capacity for hyperthermia (according to the application of an alternate magnetic field) show that these composites could be applied as a theragnostic material for a non-invasive administration such as nasal.https://www.mdpi.com/1996-1944/15/5/1755magnetic nanoparticlestheragnosticmagnetic hyperthermiacompositesnano spray dryingsuperparamagnetism |
| spellingShingle | Caio José Perecin Xavier Pierre Marie Gratens Valmir Antônio Chitta Patrícia Leo Adriano Marim de Oliveira Sérgio Akinobu Yoshioka Natália Neto Pereira Cerize Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying Materials magnetic nanoparticles theragnostic magnetic hyperthermia composites nano spray drying superparamagnetism |
| title | Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying |
| title_full | Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying |
| title_fullStr | Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying |
| title_full_unstemmed | Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying |
| title_short | Synthesis and Characterization of Magnetic Composite Theragnostics by Nano Spray Drying |
| title_sort | synthesis and characterization of magnetic composite theragnostics by nano spray drying |
| topic | magnetic nanoparticles theragnostic magnetic hyperthermia composites nano spray drying superparamagnetism |
| url | https://www.mdpi.com/1996-1944/15/5/1755 |
| work_keys_str_mv | AT caiojoseperecin synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying AT xavierpierremariegratens synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying AT valmirantoniochitta synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying AT patricialeo synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying AT adrianomarimdeoliveira synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying AT sergioakinobuyoshioka synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying AT natalianetopereiracerize synthesisandcharacterizationofmagneticcompositetheragnosticsbynanospraydrying |