Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease
A few gene loci that contribute to Alzheimer’s Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent results. Therefore, the aim of the current study is to further examine the role...
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MDPI AG
2022-09-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/10/302 |
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| author | Vasileios Siokas Polyxeni Stamati Georgia Pateraki Ioannis Liampas Athina-Maria Aloizou Daniil Tsirelis Anastasia Nousia Markos Sgantzos Grigorios Nasios Dimitrios P. Bogdanos Efthimios Dardiotis |
| author_facet | Vasileios Siokas Polyxeni Stamati Georgia Pateraki Ioannis Liampas Athina-Maria Aloizou Daniil Tsirelis Anastasia Nousia Markos Sgantzos Grigorios Nasios Dimitrios P. Bogdanos Efthimios Dardiotis |
| author_sort | Vasileios Siokas |
| collection | DOAJ |
| description | A few gene loci that contribute to Alzheimer’s Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent results. Therefore, the aim of the current study is to further examine the role of the SOD2 rs4880 in AD. We performed a case-control study with a total of 641 subjects (320 patients with probable AD, and 321 healthy controls). The statistical analysis was performed assuming five genetic models. The threshold for statistical significance was set at 0.05. The results revealed no association between SOD2 rs4880 and AD in any of the assumed genetic models that were examined [log-additive OR = 0.95 (0.76–1.19), over-dominant OR = 1.15 (0.85–1.57), recessive OR = 0.85 (0.59–1.22), dominant OR = 1.03 (0.72–1.47), and co-dominant OR1 = 1.10 (0.75–1.60) and OR2 = 0.90 (0.58–1.40)]. Adjustment for sex and subgroup analyses based on sex did not reveal any statistically significant results either. Based on our findings, SOD2 rs4880 does not appear to play a determining role in the risk of developing AD. Larger studies are warranted to elucidate the connection between rs4880 and AD. |
| first_indexed | 2024-03-09T20:27:24Z |
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| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T20:27:24Z |
| publishDate | 2022-09-01 |
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| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-9e12a53db6c14cd2bc7830176d137fcc2023-11-23T23:33:38ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-09-0144104406441410.3390/cimb44100302Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s DiseaseVasileios Siokas0Polyxeni Stamati1Georgia Pateraki2Ioannis Liampas3Athina-Maria Aloizou4Daniil Tsirelis5Anastasia Nousia6Markos Sgantzos7Grigorios Nasios8Dimitrios P. Bogdanos9Efthimios Dardiotis10Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceDepartment of Speech and Language Therapy, University of Ioannina, 45500 Ioannina, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceDepartment of Speech and Language Therapy, University of Ioannina, 45500 Ioannina, GreeceDepartment of Rheumatology and Clinical Immunology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceA few gene loci that contribute to Alzheimer’s Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent results. Therefore, the aim of the current study is to further examine the role of the SOD2 rs4880 in AD. We performed a case-control study with a total of 641 subjects (320 patients with probable AD, and 321 healthy controls). The statistical analysis was performed assuming five genetic models. The threshold for statistical significance was set at 0.05. The results revealed no association between SOD2 rs4880 and AD in any of the assumed genetic models that were examined [log-additive OR = 0.95 (0.76–1.19), over-dominant OR = 1.15 (0.85–1.57), recessive OR = 0.85 (0.59–1.22), dominant OR = 1.03 (0.72–1.47), and co-dominant OR1 = 1.10 (0.75–1.60) and OR2 = 0.90 (0.58–1.40)]. Adjustment for sex and subgroup analyses based on sex did not reveal any statistically significant results either. Based on our findings, SOD2 rs4880 does not appear to play a determining role in the risk of developing AD. Larger studies are warranted to elucidate the connection between rs4880 and AD.https://www.mdpi.com/1467-3045/44/10/302ADAlzheimer’s diseaseSOD2oxidative stressvariantrs4880 |
| spellingShingle | Vasileios Siokas Polyxeni Stamati Georgia Pateraki Ioannis Liampas Athina-Maria Aloizou Daniil Tsirelis Anastasia Nousia Markos Sgantzos Grigorios Nasios Dimitrios P. Bogdanos Efthimios Dardiotis Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease Current Issues in Molecular Biology AD Alzheimer’s disease SOD2 oxidative stress variant rs4880 |
| title | Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease |
| title_full | Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease |
| title_fullStr | Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease |
| title_full_unstemmed | Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease |
| title_short | Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease |
| title_sort | analysis of sod2 rs4880 genetic variant in patients with alzheimer s disease |
| topic | AD Alzheimer’s disease SOD2 oxidative stress variant rs4880 |
| url | https://www.mdpi.com/1467-3045/44/10/302 |
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