Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations
A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) mea...
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2021-10-01
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| author | Jacqueline Roshelli Baker Sushma Umesh Mazda Jenab Lutz Schomburg Anne Tjønneland Anja Olsen Marie-Christine Boutron-Ruault Joseph A. Rothwell Gianluca Severi Verena Katzke Theron Johnson Matthias B. Schulze Giovanna Masala Claudia Agnoli Vittorio Simeon Rosario Tumino H. Bas Bueno-de-Mesquita Inger Torhild Gram Guri Skeie Catalina Bonet Miguel Rodriguez-Barranco José María Houerta Björn Gylling Bethany Van Guelpen Aurora Perez-Cornago Elom Aglago Heinz Freisling Elisabete Weiderpass Amanda J. Cross Alicia K. Heath David J. Hughes Veronika Fedirko |
| author_facet | Jacqueline Roshelli Baker Sushma Umesh Mazda Jenab Lutz Schomburg Anne Tjønneland Anja Olsen Marie-Christine Boutron-Ruault Joseph A. Rothwell Gianluca Severi Verena Katzke Theron Johnson Matthias B. Schulze Giovanna Masala Claudia Agnoli Vittorio Simeon Rosario Tumino H. Bas Bueno-de-Mesquita Inger Torhild Gram Guri Skeie Catalina Bonet Miguel Rodriguez-Barranco José María Houerta Björn Gylling Bethany Van Guelpen Aurora Perez-Cornago Elom Aglago Heinz Freisling Elisabete Weiderpass Amanda J. Cross Alicia K. Heath David J. Hughes Veronika Fedirko |
| author_sort | Jacqueline Roshelli Baker |
| collection | DOAJ |
| description | A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; P<sub>trend</sub> = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; P<sub>trend</sub> = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; P<sub>trend</sub> = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; P<sub>trend</sub> = 0.17) for overall mortality. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability. |
| first_indexed | 2024-03-10T05:41:28Z |
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| language | English |
| last_indexed | 2024-03-10T05:41:28Z |
| publishDate | 2021-10-01 |
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| series | Biomedicines |
| spelling | doaj.art-9e137d56bf8d4c33b7b8a4b5a1adcc172023-11-22T22:29:27ZengMDPI AGBiomedicines2227-90592021-10-01911152110.3390/biomedicines9111521Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European PopulationsJacqueline Roshelli Baker0Sushma Umesh1Mazda Jenab2Lutz Schomburg3Anne Tjønneland4Anja Olsen5Marie-Christine Boutron-Ruault6Joseph A. Rothwell7Gianluca Severi8Verena Katzke9Theron Johnson10Matthias B. Schulze11Giovanna Masala12Claudia Agnoli13Vittorio Simeon14Rosario Tumino15H. Bas Bueno-de-Mesquita16Inger Torhild Gram17Guri Skeie18Catalina Bonet19Miguel Rodriguez-Barranco20José María Houerta21Björn Gylling22Bethany Van Guelpen23Aurora Perez-Cornago24Elom Aglago25Heinz Freisling26Elisabete Weiderpass27Amanda J. Cross28Alicia K. Heath29David J. Hughes30Veronika Fedirko31Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USADepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USAInternational Agency for Research on Cancer, 69372 Lyon, FranceInstitut für Experimentelle Endokrinologie, Charité—Universitätsmedizin Berlin, CVK, Südring 10, 13353 Berlin, GermanyDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, DK-2100 Copenhagen, DenmarkDanish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, DK-2100 Copenhagen, DenmarkCESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, FranceCESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, FranceCESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, 94805 Villejuif, FranceDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, GermanyCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, 50141 Florence, ItalyEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, ItalyDipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania ‘Luigi Vanvitelli’, 80121 Naples, ItalyCancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), 97100 Ragusa, ItalyCenter for Nutrition and Health, National Institute for Public Health and the Environment, 3720 Bilthoven, The NetherlandsDepartment of Community Medicine, The Arctic University of Norway, N-9037 Tromsø, NorwayDepartment of Community Medicine, The Arctic University of Norway, N-9037 Tromsø, NorwayUnitat de Nutrició i Càncer, 29010 Malaga, SpainEscuela Andaluza de Salud Pública (EASP), Instituto de Investigación Biosanitaria ibs. Granada, 18014 Granada, SpainCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, SpainDepartment of Medical Biosciences, Umea University, 901 87 Umea, SwedenDepartment of Radiation Sciences, Umea University, 901 87 Umea, SwedenCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UKInternational Agency for Research on Cancer, 69372 Lyon, FranceInternational Agency for Research on Cancer, 69372 Lyon, FranceInternational Agency for Research on Cancer, 69372 Lyon, FranceSchool of Public Health, Imperial College London, London SW7 2AZ, UKSchool of Public Health, Imperial College London, London SW7 2AZ, UKCancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, IrelandDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USAA higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; P<sub>trend</sub> = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; P<sub>trend</sub> = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; P<sub>trend</sub> = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; P<sub>trend</sub> = 0.17) for overall mortality. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability.https://www.mdpi.com/2227-9059/9/11/1521seleniumselenoprotein Pcolorectal cancersurvivalcohort |
| spellingShingle | Jacqueline Roshelli Baker Sushma Umesh Mazda Jenab Lutz Schomburg Anne Tjønneland Anja Olsen Marie-Christine Boutron-Ruault Joseph A. Rothwell Gianluca Severi Verena Katzke Theron Johnson Matthias B. Schulze Giovanna Masala Claudia Agnoli Vittorio Simeon Rosario Tumino H. Bas Bueno-de-Mesquita Inger Torhild Gram Guri Skeie Catalina Bonet Miguel Rodriguez-Barranco José María Houerta Björn Gylling Bethany Van Guelpen Aurora Perez-Cornago Elom Aglago Heinz Freisling Elisabete Weiderpass Amanda J. Cross Alicia K. Heath David J. Hughes Veronika Fedirko Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations Biomedicines selenium selenoprotein P colorectal cancer survival cohort |
| title | Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations |
| title_full | Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations |
| title_fullStr | Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations |
| title_full_unstemmed | Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations |
| title_short | Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations |
| title_sort | prediagnostic blood selenium status and mortality among patients with colorectal cancer in western european populations |
| topic | selenium selenoprotein P colorectal cancer survival cohort |
| url | https://www.mdpi.com/2227-9059/9/11/1521 |
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