Advances in the role of STAT3 in macrophage polarization
The physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has an impact on the onset and progression of a number of inflammatory immunological disorders, fibrotic diseases, and m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1160719/full |
| _version_ | 1797852931107586048 |
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| author | Tingting Xia Tingting Xia Meng Zhang Wei Lei Ruilin Yang Shengping Fu Zhenhai Fan Zhenhai Fan Ying Yang Tao Zhang Tao Zhang Tao Zhang |
| author_facet | Tingting Xia Tingting Xia Meng Zhang Wei Lei Ruilin Yang Shengping Fu Zhenhai Fan Zhenhai Fan Ying Yang Tao Zhang Tao Zhang Tao Zhang |
| author_sort | Tingting Xia |
| collection | DOAJ |
| description | The physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has an impact on the onset and progression of a number of inflammatory immunological disorders, fibrotic diseases, and malignancies. In order to produce the necessary biological effects, macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types in response to various microenvironmental stimuli. STAT3 signaling is involved in macrophage polarization, and the research of the effect of STAT3 on macrophage polarization has gained attention in recent years. In order to provide references for the treatment and investigation of disorders related to macrophage polarization, this review compiles the pertinent signaling pathways associated with STAT3 and macrophage polarization from many fundamental studies. |
| first_indexed | 2024-04-09T19:42:18Z |
| format | Article |
| id | doaj.art-9e144b2d2642496c818459427107a7b3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T19:42:18Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9e144b2d2642496c818459427107a7b32023-04-04T05:03:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-04-011410.3389/fimmu.2023.11607191160719Advances in the role of STAT3 in macrophage polarizationTingting Xia0Tingting Xia1Meng Zhang2Wei Lei3Ruilin Yang4Shengping Fu5Zhenhai Fan6Zhenhai Fan7Ying Yang8Tao Zhang9Tao Zhang10Tao Zhang11Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaThe Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaThe Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, ChinaThe physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to STAT3, and it has been demonstrated that aberrant STAT3 expression has an impact on the onset and progression of a number of inflammatory immunological disorders, fibrotic diseases, and malignancies. In order to produce the necessary biological effects, macrophages (M0) can be polarized into pro-inflammatory (M1) and anti-inflammatory (M2) types in response to various microenvironmental stimuli. STAT3 signaling is involved in macrophage polarization, and the research of the effect of STAT3 on macrophage polarization has gained attention in recent years. In order to provide references for the treatment and investigation of disorders related to macrophage polarization, this review compiles the pertinent signaling pathways associated with STAT3 and macrophage polarization from many fundamental studies.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1160719/fullSTAT3M1 macrophageM2 macrophagesignaling pathwaymacrophage polarization |
| spellingShingle | Tingting Xia Tingting Xia Meng Zhang Wei Lei Ruilin Yang Shengping Fu Zhenhai Fan Zhenhai Fan Ying Yang Tao Zhang Tao Zhang Tao Zhang Advances in the role of STAT3 in macrophage polarization Frontiers in Immunology STAT3 M1 macrophage M2 macrophage signaling pathway macrophage polarization |
| title | Advances in the role of STAT3 in macrophage polarization |
| title_full | Advances in the role of STAT3 in macrophage polarization |
| title_fullStr | Advances in the role of STAT3 in macrophage polarization |
| title_full_unstemmed | Advances in the role of STAT3 in macrophage polarization |
| title_short | Advances in the role of STAT3 in macrophage polarization |
| title_sort | advances in the role of stat3 in macrophage polarization |
| topic | STAT3 M1 macrophage M2 macrophage signaling pathway macrophage polarization |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1160719/full |
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