Long noncoding RNA study: Genome-wide approaches
Long noncoding RNAs (lncRNAs) have been confirmed to play a crucial role in various biological processes across several species. Though many efforts have been devoted to the expansion of the lncRNAs landscape, much about lncRNAs is still unknown due to their great complexity. The development of high...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-11-01
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| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222002963 |
| _version_ | 1797762806265675776 |
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| author | Shuang Tao Yarui Hou Liting Diao Yanxia Hu Wanyi Xu Shujuan Xie Zhendong Xiao |
| author_facet | Shuang Tao Yarui Hou Liting Diao Yanxia Hu Wanyi Xu Shujuan Xie Zhendong Xiao |
| author_sort | Shuang Tao |
| collection | DOAJ |
| description | Long noncoding RNAs (lncRNAs) have been confirmed to play a crucial role in various biological processes across several species. Though many efforts have been devoted to the expansion of the lncRNAs landscape, much about lncRNAs is still unknown due to their great complexity. The development of high-throughput technologies and the constantly improved bioinformatic methods have resulted in a rapid expansion of lncRNA research and relevant databases. In this review, we introduced genome-wide research of lncRNAs in three parts: (i) novel lncRNA identification by high-throughput sequencing and computational pipelines; (ii) functional characterization of lncRNAs by expression atlas profiling, genome-scale screening, and the research of cancer-related lncRNAs; (iii) mechanism research by large-scale experimental technologies and computational analysis. Besides, primary experimental methods and bioinformatic pipelines related to these three parts are summarized. This review aimed to provide a comprehensive and systemic overview of lncRNA genome-wide research strategies and indicate a genome-wide lncRNA research system. |
| first_indexed | 2024-03-12T19:32:45Z |
| format | Article |
| id | doaj.art-9e1513df0708452ca2ad55c72459f6e9 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T19:32:45Z |
| publishDate | 2023-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-9e1513df0708452ca2ad55c72459f6e92023-08-02T04:24:27ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-11-0110624912510Long noncoding RNA study: Genome-wide approachesShuang Tao0Yarui Hou1Liting Diao2Yanxia Hu3Wanyi Xu4Shujuan Xie5Zhendong Xiao6The Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Institute of Vaccine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Corresponding author. Institute of Vaccine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaThe Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Corresponding author.Long noncoding RNAs (lncRNAs) have been confirmed to play a crucial role in various biological processes across several species. Though many efforts have been devoted to the expansion of the lncRNAs landscape, much about lncRNAs is still unknown due to their great complexity. The development of high-throughput technologies and the constantly improved bioinformatic methods have resulted in a rapid expansion of lncRNA research and relevant databases. In this review, we introduced genome-wide research of lncRNAs in three parts: (i) novel lncRNA identification by high-throughput sequencing and computational pipelines; (ii) functional characterization of lncRNAs by expression atlas profiling, genome-scale screening, and the research of cancer-related lncRNAs; (iii) mechanism research by large-scale experimental technologies and computational analysis. Besides, primary experimental methods and bioinformatic pipelines related to these three parts are summarized. This review aimed to provide a comprehensive and systemic overview of lncRNA genome-wide research strategies and indicate a genome-wide lncRNA research system.http://www.sciencedirect.com/science/article/pii/S2352304222002963Cancer-related lncRNAsComputational pipelinesGenome-wide studyLong noncoding RNAsTechnological approaches |
| spellingShingle | Shuang Tao Yarui Hou Liting Diao Yanxia Hu Wanyi Xu Shujuan Xie Zhendong Xiao Long noncoding RNA study: Genome-wide approaches Genes and Diseases Cancer-related lncRNAs Computational pipelines Genome-wide study Long noncoding RNAs Technological approaches |
| title | Long noncoding RNA study: Genome-wide approaches |
| title_full | Long noncoding RNA study: Genome-wide approaches |
| title_fullStr | Long noncoding RNA study: Genome-wide approaches |
| title_full_unstemmed | Long noncoding RNA study: Genome-wide approaches |
| title_short | Long noncoding RNA study: Genome-wide approaches |
| title_sort | long noncoding rna study genome wide approaches |
| topic | Cancer-related lncRNAs Computational pipelines Genome-wide study Long noncoding RNAs Technological approaches |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222002963 |
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