Steroid-induced hypokalemic periodic paralysis: a case report and literature review
Abstract Background Hypokalemic periodic paralysis (HPP) is a rare channelopathy characterized by episodic attacks of acute muscle weakness concomitant with hypokalemia. The etiology of hypokalemia is the shift of potassium into the cells, and the clinical symptoms resolve when potassium starts to l...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-023-03131-3 |
| _version_ | 1797860038471057408 |
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| author | Haw-Ting Tai Po-Tsang Lee Shih-Hsiang Ou |
| author_facet | Haw-Ting Tai Po-Tsang Lee Shih-Hsiang Ou |
| author_sort | Haw-Ting Tai |
| collection | DOAJ |
| description | Abstract Background Hypokalemic periodic paralysis (HPP) is a rare channelopathy characterized by episodic attacks of acute muscle weakness concomitant with hypokalemia. The etiology of hypokalemia is the shift of potassium into the cells, and the clinical symptoms resolve when potassium starts to leak back to the serum. Most of the time, the underlying ion channel defects are well compensated, and an additional trigger is often required to initiate an attack. Well-known trigger factors include carbohydrate-rich meals, exercise followed by rest, stress, cold weather, and alcohol consumption. Case presentation Here, we present the case of a 26-year-old Asian man who suffered from an acute onset of bilateral lower limb weakness with hypokalemia following dexamethasone injection. He was diagnosed with HPP. Conclusions We would like to remind physicians to think of steroids as an unusual precipitating factor while managing patients with HPP, per results of this case study. |
| first_indexed | 2024-04-09T21:39:15Z |
| format | Article |
| id | doaj.art-9e1a6654390c4cd69b4ac3cba69a0655 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-09T21:39:15Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-9e1a6654390c4cd69b4ac3cba69a06552023-03-26T11:07:52ZengBMCBMC Nephrology1471-23692023-03-012411510.1186/s12882-023-03131-3Steroid-induced hypokalemic periodic paralysis: a case report and literature reviewHaw-Ting Tai0Po-Tsang Lee1Shih-Hsiang Ou2Division of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General HospitalDivision of Nephrology, Department of Internal Medicine, Kaohsiung Veterans General HospitalDivision of Nephrology, Department of Internal Medicine, Pingtung Veterans General HospitalAbstract Background Hypokalemic periodic paralysis (HPP) is a rare channelopathy characterized by episodic attacks of acute muscle weakness concomitant with hypokalemia. The etiology of hypokalemia is the shift of potassium into the cells, and the clinical symptoms resolve when potassium starts to leak back to the serum. Most of the time, the underlying ion channel defects are well compensated, and an additional trigger is often required to initiate an attack. Well-known trigger factors include carbohydrate-rich meals, exercise followed by rest, stress, cold weather, and alcohol consumption. Case presentation Here, we present the case of a 26-year-old Asian man who suffered from an acute onset of bilateral lower limb weakness with hypokalemia following dexamethasone injection. He was diagnosed with HPP. Conclusions We would like to remind physicians to think of steroids as an unusual precipitating factor while managing patients with HPP, per results of this case study.https://doi.org/10.1186/s12882-023-03131-3Hypokalemic periodic paralysisChannelopathyGlucocorticoids |
| spellingShingle | Haw-Ting Tai Po-Tsang Lee Shih-Hsiang Ou Steroid-induced hypokalemic periodic paralysis: a case report and literature review BMC Nephrology Hypokalemic periodic paralysis Channelopathy Glucocorticoids |
| title | Steroid-induced hypokalemic periodic paralysis: a case report and literature review |
| title_full | Steroid-induced hypokalemic periodic paralysis: a case report and literature review |
| title_fullStr | Steroid-induced hypokalemic periodic paralysis: a case report and literature review |
| title_full_unstemmed | Steroid-induced hypokalemic periodic paralysis: a case report and literature review |
| title_short | Steroid-induced hypokalemic periodic paralysis: a case report and literature review |
| title_sort | steroid induced hypokalemic periodic paralysis a case report and literature review |
| topic | Hypokalemic periodic paralysis Channelopathy Glucocorticoids |
| url | https://doi.org/10.1186/s12882-023-03131-3 |
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