Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system

Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system

Abstract Background Hepatic lipidosis is increasing in incidence in the Western world, with cats being particularly sensitive. When cats stop eating and start utilizing their fat reserves, free fatty acids (FFAs) increase in blood, causing an accumulation of triacylglycerol (TAG) in the liver. Objec...

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Bibliographic Details
Main Authors:	Maya W. Haaker, Hedwig S. Kruitwagen, Arie B. Vaandrager, Martin Houweling, Louis C. Penning, Martijn R. Molenaar, Monique E. vanWolferen, Loes A. Oosterhoff, Bart Spee, J. Bernd Helms
Format:	Article
Language:	English
Published:	Wiley 2020-01-01
Series:	Journal of Veterinary Internal Medicine
Subjects:	AICAR diacylglycerol O‐acyltransferase 1 inhibitor hepatic organoids perilipin 2 steatosis
Online Access:	https://doi.org/10.1111/jvim.15670

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