Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial
Background This study assessed the effect of a single bolus administration of lidocaine on the prevention of tourniquet-induced hypertension (TIH) and compared the effect of lidocaine to that of ketamine in patients undergoing general anesthesia. Methods This randomized, controlled, double-blind stu...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Anesthesiologists
2022-01-01
|
| Series: | Anesthesia and Pain Medicine |
| Subjects: | |
| Online Access: | http://www.anesth-pain-med.org/upload/pdf/apm-21055.pdf |
| _version_ | 1797825404969418752 |
|---|---|
| author | Ji WooK Kim A Ran Lee Eun Sun Park Min Su Yun Sung Won Ryu Uk Gwan Kim Dong Hee Kang Ju Deok Kim |
| author_facet | Ji WooK Kim A Ran Lee Eun Sun Park Min Su Yun Sung Won Ryu Uk Gwan Kim Dong Hee Kang Ju Deok Kim |
| author_sort | Ji WooK Kim |
| collection | DOAJ |
| description | Background This study assessed the effect of a single bolus administration of lidocaine on the prevention of tourniquet-induced hypertension (TIH) and compared the effect of lidocaine to that of ketamine in patients undergoing general anesthesia. Methods This randomized, controlled, double-blind study included 75 patients who underwent lower limb surgery using a tourniquet. The patients were administered lidocaine (1.5 mg/kg, n = 25), ketamine (0.2 mg/kg, n = 25) or placebo (n = 25). The study drugs were administered intravenously 10 min before tourniquet inflation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured before tourniquet inflation, after tourniquet inflation for 60 min at 10 min intervals, and immediately after tourniquet deflation. The incidence of TIH, defined as an increase of 30% or more in SBP or DBP during tourniquet inflation, was also recorded. Results SBP, DBP, and HR increased significantly over time in the control group compared to those in the lidocaine and ketamine groups for 60 min after tourniquet inflation (P < 0.001, P < 0.001, and P = 0.007, respectively). The incidence of TIH was significantly lower in the lidocaine (n = 4, 16%) and ketamine (n = 3, 12%) group than in the control group (n = 14, 56%) (P = 0.001). Conclusion Single-bolus lidocaine effectively attenuated blood pressure increase due to tourniquet inflation, with an effect comparable to that of bolus ketamine. |
| first_indexed | 2024-03-13T10:53:32Z |
| format | Article |
| id | doaj.art-9e1ac56410424c0cb0ea16048c1160bf |
| institution | Directory Open Access Journal |
| issn | 1975-5171 2383-7977 |
| language | English |
| last_indexed | 2024-03-13T10:53:32Z |
| publishDate | 2022-01-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Anesthesia and Pain Medicine |
| spelling | doaj.art-9e1ac56410424c0cb0ea16048c1160bf2023-05-17T05:54:19ZengKorean Society of AnesthesiologistsAnesthesia and Pain Medicine1975-51712383-79772022-01-01171354310.17085/apm.210551100Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trialJi WooK Kim0A Ran Lee1Eun Sun Park2Min Su Yun3Sung Won Ryu4Uk Gwan Kim5Dong Hee Kang6Ju Deok Kim7 Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan, Korea Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, Ulsan, Korea Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, Korea Department of Anesthesiology and Pain Medicine, Kosin University College of Medicine, Busan, KoreaBackground This study assessed the effect of a single bolus administration of lidocaine on the prevention of tourniquet-induced hypertension (TIH) and compared the effect of lidocaine to that of ketamine in patients undergoing general anesthesia. Methods This randomized, controlled, double-blind study included 75 patients who underwent lower limb surgery using a tourniquet. The patients were administered lidocaine (1.5 mg/kg, n = 25), ketamine (0.2 mg/kg, n = 25) or placebo (n = 25). The study drugs were administered intravenously 10 min before tourniquet inflation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were measured before tourniquet inflation, after tourniquet inflation for 60 min at 10 min intervals, and immediately after tourniquet deflation. The incidence of TIH, defined as an increase of 30% or more in SBP or DBP during tourniquet inflation, was also recorded. Results SBP, DBP, and HR increased significantly over time in the control group compared to those in the lidocaine and ketamine groups for 60 min after tourniquet inflation (P < 0.001, P < 0.001, and P = 0.007, respectively). The incidence of TIH was significantly lower in the lidocaine (n = 4, 16%) and ketamine (n = 3, 12%) group than in the control group (n = 14, 56%) (P = 0.001). Conclusion Single-bolus lidocaine effectively attenuated blood pressure increase due to tourniquet inflation, with an effect comparable to that of bolus ketamine.http://www.anesth-pain-med.org/upload/pdf/apm-21055.pdfhypertensionketaminelidocainepaintourniquets |
| spellingShingle | Ji WooK Kim A Ran Lee Eun Sun Park Min Su Yun Sung Won Ryu Uk Gwan Kim Dong Hee Kang Ju Deok Kim Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial Anesthesia and Pain Medicine hypertension ketamine lidocaine pain tourniquets |
| title | Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial |
| title_full | Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial |
| title_fullStr | Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial |
| title_full_unstemmed | Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial |
| title_short | Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial |
| title_sort | comparison of bolus administration effects of lidocaine on preventing tourniquet induced hypertension in patients undergoing general anesthesia a randomized controlled trial |
| topic | hypertension ketamine lidocaine pain tourniquets |
| url | http://www.anesth-pain-med.org/upload/pdf/apm-21055.pdf |
| work_keys_str_mv | AT jiwookkim comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT aranlee comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT eunsunpark comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT minsuyun comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT sungwonryu comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT ukgwankim comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT dongheekang comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial AT judeokkim comparisonofbolusadministrationeffectsoflidocaineonpreventingtourniquetinducedhypertensioninpatientsundergoinggeneralanesthesiaarandomizedcontrolledtrial |