Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway

Abstract Background The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the heart by mimicking the cardioprotective effects of ischaemic postconditioning (IP). Methods We used a myocardial reperfusion injury rat m...

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Bibliographic Details
Main Authors: Fuhua Wang, Huan Wang, Xuejing Liu, Haiyi Yu, Bo Zuo, Zhu Song, Ning Wang, Wei Huang, Guisong Wang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Medicine
Subjects:
Neuregulin-1
Pharmacological postconditioning
Ischaemic postconditioning
Myocardial reperfusion injury
ErbB4
Online Access:http://link.springer.com/article/10.1186/s10020-018-0040-7

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http://link.springer.com/article/10.1186/s10020-018-0040-7

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