Mechanisms of spindle bipolarity establishment in acentrosomal human cells
Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells. However, the detailed mechanisms describing how spindle bipolarity is established without centrosomes are not completely understood. We hav...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1743899 |
| _version_ | 1797677157938364416 |
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| author | Kaho Hashimoto Takumi Chinen Daiju Kitagawa |
| author_facet | Kaho Hashimoto Takumi Chinen Daiju Kitagawa |
| author_sort | Kaho Hashimoto |
| collection | DOAJ |
| description | Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells. However, the detailed mechanisms describing how spindle bipolarity is established without centrosomes are not completely understood. We have recently demonstrated that in acentrosomal human cells, nuclear mitotic apparatus protein (NuMA) assemblies-mediated microtubule asters and EG5 promote spindle bipolarization in early mitosis. |
| first_indexed | 2024-03-11T22:40:59Z |
| format | Article |
| id | doaj.art-9e1c6951387540f6a9e7db417b1359e7 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:59Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-9e1c6951387540f6a9e7db417b1359e72023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-05-017310.1080/23723556.2020.17438991743899Mechanisms of spindle bipolarity establishment in acentrosomal human cellsKaho Hashimoto0Takumi Chinen1Daiju Kitagawa2The University of TokyoThe University of TokyoThe University of TokyoCentrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells. However, the detailed mechanisms describing how spindle bipolarity is established without centrosomes are not completely understood. We have recently demonstrated that in acentrosomal human cells, nuclear mitotic apparatus protein (NuMA) assemblies-mediated microtubule asters and EG5 promote spindle bipolarization in early mitosis.http://dx.doi.org/10.1080/23723556.2020.1743899acentrosomal spindlespindle bipolaritynuma |
| spellingShingle | Kaho Hashimoto Takumi Chinen Daiju Kitagawa Mechanisms of spindle bipolarity establishment in acentrosomal human cells Molecular & Cellular Oncology acentrosomal spindle spindle bipolarity numa |
| title | Mechanisms of spindle bipolarity establishment in acentrosomal human cells |
| title_full | Mechanisms of spindle bipolarity establishment in acentrosomal human cells |
| title_fullStr | Mechanisms of spindle bipolarity establishment in acentrosomal human cells |
| title_full_unstemmed | Mechanisms of spindle bipolarity establishment in acentrosomal human cells |
| title_short | Mechanisms of spindle bipolarity establishment in acentrosomal human cells |
| title_sort | mechanisms of spindle bipolarity establishment in acentrosomal human cells |
| topic | acentrosomal spindle spindle bipolarity numa |
| url | http://dx.doi.org/10.1080/23723556.2020.1743899 |
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