Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta
A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably,...
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MDPI AG
2022-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/192 |
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| author | Alexander Yu. Gorodkov Yuriy M. Tsygankov Alexey D. Shepelev Sergey V. Krasheninnikov Shota T. Zhorzholiani Andrey V. Agafonov Vissarion G. Mamagulashvili Dmitriy V. Savinov Timur Kh. Tenchurin Sergey N. Chvalun |
| author_facet | Alexander Yu. Gorodkov Yuriy M. Tsygankov Alexey D. Shepelev Sergey V. Krasheninnikov Shota T. Zhorzholiani Andrey V. Agafonov Vissarion G. Mamagulashvili Dmitriy V. Savinov Timur Kh. Tenchurin Sergey N. Chvalun |
| author_sort | Alexander Yu. Gorodkov |
| collection | DOAJ |
| description | A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel. |
| first_indexed | 2024-03-09T16:16:01Z |
| format | Article |
| id | doaj.art-9e1d7986a32d478cb8f106d71ecc0a51 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:16:01Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-9e1d7986a32d478cb8f106d71ecc0a512023-11-24T15:49:13ZengMDPI AGJournal of Functional Biomaterials2079-49832022-10-0113419210.3390/jfb13040192Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the AortaAlexander Yu. Gorodkov0Yuriy M. Tsygankov1Alexey D. Shepelev2Sergey V. Krasheninnikov3Shota T. Zhorzholiani4Andrey V. Agafonov5Vissarion G. Mamagulashvili6Dmitriy V. Savinov7Timur Kh. Tenchurin8Sergey N. Chvalun9A.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Rublevskoye Highway 135, 121552 Moscow, RussiaA.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Rublevskoye Highway 135, 121552 Moscow, RussiaNational Research Centre “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182 Moscow, RussiaNational Research Centre “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182 Moscow, RussiaA.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Rublevskoye Highway 135, 121552 Moscow, RussiaA.N. Bakulev National Medical Research Center for Cardiovascular Surgery, Rublevskoye Highway 135, 121552 Moscow, RussiaNational Research Centre “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182 Moscow, RussiaNational Research Centre “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182 Moscow, RussiaNational Research Centre “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182 Moscow, RussiaNational Research Centre “Kurchatov Institute”, Akademika Kurchatova pl. 1, 123182 Moscow, RussiaA significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel.https://www.mdpi.com/2079-4983/13/4/192vascular prosthesescopolymers of vinylidene fluoride with hexafluoropropyleneelectrospinningmimic the mechanical properties of native vesselsrestoration of the neovessel |
| spellingShingle | Alexander Yu. Gorodkov Yuriy M. Tsygankov Alexey D. Shepelev Sergey V. Krasheninnikov Shota T. Zhorzholiani Andrey V. Agafonov Vissarion G. Mamagulashvili Dmitriy V. Savinov Timur Kh. Tenchurin Sergey N. Chvalun Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta Journal of Functional Biomaterials vascular prostheses copolymers of vinylidene fluoride with hexafluoropropylene electrospinning mimic the mechanical properties of native vessels restoration of the neovessel |
| title | Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta |
| title_full | Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta |
| title_fullStr | Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta |
| title_full_unstemmed | Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta |
| title_short | Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta |
| title_sort | influence of γ radiation on mechanical stability to cyclic loads tubular elastic matrix of the aorta |
| topic | vascular prostheses copolymers of vinylidene fluoride with hexafluoropropylene electrospinning mimic the mechanical properties of native vessels restoration of the neovessel |
| url | https://www.mdpi.com/2079-4983/13/4/192 |
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