Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases
Abstract. Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendosco...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-08-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002339 |
| _version_ | 1797978572731711488 |
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| author | Yun Wang Sheng Zhang Thomas J. Borody Faming Zhang Yuanyuan Ji |
| author_facet | Yun Wang Sheng Zhang Thomas J. Borody Faming Zhang Yuanyuan Ji |
| author_sort | Yun Wang |
| collection | DOAJ |
| description | Abstract. Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendoscopic enteral tubing (TET) for microbiota delivery, and purified Firmicutes spores from fecal matter. To improve the understanding of the clinical applications of FMT, we performed a systematic literature review on FMT published from 2011 to 2021. Here, we provided an overview of the reported clinical benefits of FMT, the methodology of processing FMT, the strategy of using FMT, and the regulations on FMT from a global perspective. A total of 782 studies were included for the final analysis. The present review profiled the effectiveness from all clinical FMT uses in 85 specific diseases as eight categories, including infections, gut diseases, microbiota–gut–liver axis, microbiota–gut–brain axis, metabolic diseases, oncology, hematological diseases, and other diseases. Although many further controlled trials will be needed, the dramatic increasing reports have shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut. |
| first_indexed | 2024-04-11T05:25:06Z |
| format | Article |
| id | doaj.art-9e1ec09e0bef4156ba08500898025776 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-04-11T05:25:06Z |
| publishDate | 2022-08-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-9e1ec09e0bef4156ba085008980257762022-12-23T07:54:46ZengWolters KluwerChinese Medical Journal0366-69992542-56412022-08-01135161927193910.1097/CM9.0000000000002339202208200-00005Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseasesYun WangSheng ZhangThomas J. BorodyFaming ZhangYuanyuan JiAbstract. Fecal microbiota transplantation (FMT) has been used as a core therapy for treating dysbiosis-related diseases by remodeling gut microbiota. The methodology and technology for improving FMT are stepping forward, mainly including washed microbiota transplantation (WMT), colonic transendoscopic enteral tubing (TET) for microbiota delivery, and purified Firmicutes spores from fecal matter. To improve the understanding of the clinical applications of FMT, we performed a systematic literature review on FMT published from 2011 to 2021. Here, we provided an overview of the reported clinical benefits of FMT, the methodology of processing FMT, the strategy of using FMT, and the regulations on FMT from a global perspective. A total of 782 studies were included for the final analysis. The present review profiled the effectiveness from all clinical FMT uses in 85 specific diseases as eight categories, including infections, gut diseases, microbiota–gut–liver axis, microbiota–gut–brain axis, metabolic diseases, oncology, hematological diseases, and other diseases. Although many further controlled trials will be needed, the dramatic increasing reports have shown the promising future of FMT for dysbiosis-related diseases in the gut or beyond the gut.http://journals.lww.com/10.1097/CM9.0000000000002339 |
| spellingShingle | Yun Wang Sheng Zhang Thomas J. Borody Faming Zhang Yuanyuan Ji Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases Chinese Medical Journal |
| title | Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases |
| title_full | Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases |
| title_fullStr | Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases |
| title_full_unstemmed | Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases |
| title_short | Encyclopedia of fecal microbiota transplantation: a review of effectiveness in the treatment of 85 diseases |
| title_sort | encyclopedia of fecal microbiota transplantation a review of effectiveness in the treatment of 85 diseases |
| url | http://journals.lww.com/10.1097/CM9.0000000000002339 |
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