Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis
Background: Recently, many research studies with equivocal results, have found Neonatal Sepsis (NS) biomarkers and focused on single regions. Therefore, the aim of this study was to evaluate serum and urine C - Reactive Protein (CRP), Mean Platelet Volume (MPV) and Neutrophil/ Lymphocyte Ratio (NLR)...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-04-01
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| Series: | International Journal of Pediatrics |
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| Online Access: | https://ijp.mums.ac.ir/article_22231_0d7fe75cfe53daf74815fc452d9b1945.pdf |
| _version_ | 1797705404077047808 |
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| author | Babak Soltani mohammad Reza Sharif Ahmad Safari Mohammad Javad Azadchehr MohammadMahdi Heidari Nafiseh Aliabadi Rasoul Etesam por |
| author_facet | Babak Soltani mohammad Reza Sharif Ahmad Safari Mohammad Javad Azadchehr MohammadMahdi Heidari Nafiseh Aliabadi Rasoul Etesam por |
| author_sort | Babak Soltani |
| collection | DOAJ |
| description | Background: Recently, many research studies with equivocal results, have found Neonatal Sepsis (NS) biomarkers and focused on single regions. Therefore, the aim of this study was to evaluate serum and urine C - Reactive Protein (CRP), Mean Platelet Volume (MPV) and Neutrophil/ Lymphocyte Ratio (NLR) as diagnostic values in NS.Materials and Methods: This case-control study was performed on 147 cases (79 overweight or obese children and 68 normal weight children). For evaluating quality of life, the original version of the PedsQL, quality of life questionnaire, was used.Methods: This descriptive-analytical research analyzed Shahid Beheshti Hospital’s probable NS patients. All individuals got a complete blood count, white blood differential, CRP, blood culture, and urine culture. Data was analyzed by SPSS v24.Results: The data indicated that NS infants had substantially higher mean serum levels of MPV (10.63 ± 1.03 vs. 8.63 ± 0.96, P<0.001), NLR (2.08 ± 1.24 vs. 1.01 ± 0.5, P<0.001), and CRP (12.97 ± 5.09 vs 5.83 ± 2.6 and 9.61 ± 3.25 vs 4.9 ± 3.4, P<0.001).The optimum cut-off points for serum and urine CRP, NLR, and MVP were 10, 6.7, 1.2, and 9.5. The highest Area under the Curve (AUC) was detected in MPV (0.909), and the other AUC for serum and urine CRP and NLR were 0.872, 0.831, and 0.804, respectively. Serum CRP had the lowest sensitivity (73.3%) among urine, NLR, and MPV. Serum CRP had the best specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV), identified as 96.7 %, 88%, and 90%, respectively.Conclusion: Sepsis increases MPV, serum and urine CRP, and NLR in neonates. MPV and serum CRP may detect NS early. |
| first_indexed | 2024-03-12T05:35:43Z |
| format | Article |
| id | doaj.art-9e201dd69aa1468086155d91cdf0eedd |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-03-12T05:35:43Z |
| publishDate | 2023-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-9e201dd69aa1468086155d91cdf0eedd2023-09-03T06:29:28ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552023-04-01114176361764510.22038/ijp.2023.70675.519822231Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal SepsisBabak Soltani0mohammad Reza Sharif1Ahmad Safari2Mohammad Javad Azadchehr3MohammadMahdi Heidari4Nafiseh Aliabadi5Rasoul Etesam por6Associate professor of pediatrics diseases, Department of Pediatrics, School of Medicine, Infectious Diseases Research Center, Shahid Beheshti Hospital, Kashan University of Medical SciencesInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, IranDepartment of Pediatrics, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical SciencesInfectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, IranDepartment of Pediatric, Kashan University of Medical Sciences, Kashan, IranDepartment of Pediatric , Kashan University of Medical Sciences, Kashan, IranStudent Research Committee, Kashan University of Medical Sciences, Kashan, Iran.Background: Recently, many research studies with equivocal results, have found Neonatal Sepsis (NS) biomarkers and focused on single regions. Therefore, the aim of this study was to evaluate serum and urine C - Reactive Protein (CRP), Mean Platelet Volume (MPV) and Neutrophil/ Lymphocyte Ratio (NLR) as diagnostic values in NS.Materials and Methods: This case-control study was performed on 147 cases (79 overweight or obese children and 68 normal weight children). For evaluating quality of life, the original version of the PedsQL, quality of life questionnaire, was used.Methods: This descriptive-analytical research analyzed Shahid Beheshti Hospital’s probable NS patients. All individuals got a complete blood count, white blood differential, CRP, blood culture, and urine culture. Data was analyzed by SPSS v24.Results: The data indicated that NS infants had substantially higher mean serum levels of MPV (10.63 ± 1.03 vs. 8.63 ± 0.96, P<0.001), NLR (2.08 ± 1.24 vs. 1.01 ± 0.5, P<0.001), and CRP (12.97 ± 5.09 vs 5.83 ± 2.6 and 9.61 ± 3.25 vs 4.9 ± 3.4, P<0.001).The optimum cut-off points for serum and urine CRP, NLR, and MVP were 10, 6.7, 1.2, and 9.5. The highest Area under the Curve (AUC) was detected in MPV (0.909), and the other AUC for serum and urine CRP and NLR were 0.872, 0.831, and 0.804, respectively. Serum CRP had the lowest sensitivity (73.3%) among urine, NLR, and MPV. Serum CRP had the best specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV), identified as 96.7 %, 88%, and 90%, respectively.Conclusion: Sepsis increases MPV, serum and urine CRP, and NLR in neonates. MPV and serum CRP may detect NS early.https://ijp.mums.ac.ir/article_22231_0d7fe75cfe53daf74815fc452d9b1945.pdfc - reactive protein,,,،mean platelet volume,,,،neutrophil/ lymphocyte ratio,,,،neonatal sepsis |
| spellingShingle | Babak Soltani mohammad Reza Sharif Ahmad Safari Mohammad Javad Azadchehr MohammadMahdi Heidari Nafiseh Aliabadi Rasoul Etesam por Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis International Journal of Pediatrics c - reactive protein,, ,،mean platelet volume,, ,،neutrophil/ lymphocyte ratio,, ,،neonatal sepsis |
| title | Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis |
| title_full | Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis |
| title_fullStr | Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis |
| title_full_unstemmed | Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis |
| title_short | Serum and Urine C - Reactive Protein, Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio as Diagnostic Values in Neonatal Sepsis |
| title_sort | serum and urine c reactive protein mean platelet volume and neutrophil lymphocyte ratio as diagnostic values in neonatal sepsis |
| topic | c - reactive protein,, ,،mean platelet volume,, ,،neutrophil/ lymphocyte ratio,, ,،neonatal sepsis |
| url | https://ijp.mums.ac.ir/article_22231_0d7fe75cfe53daf74815fc452d9b1945.pdf |
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