Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation
Oocyte cryopreservation has drastically improved in recent years and is receiving widespread clinical use with increasing demand for fertility preservation and assisted reproduction treatments. However, there are still several points to be reviewed in terms of suppressing sub-lethal damages and impr...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2019-03-01
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| Series: | European Medical Journal |
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| Online Access: | https://www.emjreviews.com/reproductive-health/article/updating-the-impact-of-lipid-metabolism-modulation-and-lipidomic-profiling-on-oocyte-cryopreservation/ |
| _version_ | 1818503371118608384 |
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| author | Eduardo Domingos Borges Alessandra Aparecida Vireque |
| author_facet | Eduardo Domingos Borges Alessandra Aparecida Vireque |
| author_sort | Eduardo Domingos Borges |
| collection | DOAJ |
| description | Oocyte cryopreservation has drastically improved in recent years and is receiving widespread clinical use with increasing demand for fertility preservation and assisted reproduction treatments. However, there are still several points to be reviewed in terms of suppressing sub-lethal damages and improving overall safety, especially when trying to preserve oocytes at the germinal vesicle stage or oocytes matured in vitro. The lipid content of oocytes is highly associated with both their competence and cryotolerance. Differences in lipid content are observed not just between different species but also at different developmental stages and when the oocytes are kept under different conditions, including cryopreservation. Many efforts have been made to understand how physiological or in vitro alterations in the lipid profile of oocytes impacts cryotolerance and vice-versa; however, the dynamics of cytosolic and membrane lipid involvement in the cryopreservation process remains poorly clarified in the human female gamete. This review presents an updated overview of the current state of cryopreservation techniques and oocyte lipidomics and highlights possible ways to improve cryotolerance, focussing on lipid content modulation. |
| first_indexed | 2024-12-10T21:23:08Z |
| format | Article |
| id | doaj.art-9e215194dd92471ba14a6a452a90dfe6 |
| institution | Directory Open Access Journal |
| issn | 2397-6764 |
| language | English |
| last_indexed | 2024-12-10T21:23:08Z |
| publishDate | 2019-03-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal |
| spelling | doaj.art-9e215194dd92471ba14a6a452a90dfe62022-12-22T01:33:03ZengEuropean Medical JournalEuropean Medical Journal2397-67642019-03-01417987Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte CryopreservationEduardo Domingos Borges0Alessandra Aparecida Vireque1Department of Obstetrics and Gynecology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilInvitra – Assisted Reproductive Technologies Ltd., Supera Innovation and Technology Park, Ribeirão Preto, BrazilOocyte cryopreservation has drastically improved in recent years and is receiving widespread clinical use with increasing demand for fertility preservation and assisted reproduction treatments. However, there are still several points to be reviewed in terms of suppressing sub-lethal damages and improving overall safety, especially when trying to preserve oocytes at the germinal vesicle stage or oocytes matured in vitro. The lipid content of oocytes is highly associated with both their competence and cryotolerance. Differences in lipid content are observed not just between different species but also at different developmental stages and when the oocytes are kept under different conditions, including cryopreservation. Many efforts have been made to understand how physiological or in vitro alterations in the lipid profile of oocytes impacts cryotolerance and vice-versa; however, the dynamics of cytosolic and membrane lipid involvement in the cryopreservation process remains poorly clarified in the human female gamete. This review presents an updated overview of the current state of cryopreservation techniques and oocyte lipidomics and highlights possible ways to improve cryotolerance, focussing on lipid content modulation.https://www.emjreviews.com/reproductive-health/article/updating-the-impact-of-lipid-metabolism-modulation-and-lipidomic-profiling-on-oocyte-cryopreservation/cryopreservationlipid metabolismlipid profilemass spectrometryoocyte |
| spellingShingle | Eduardo Domingos Borges Alessandra Aparecida Vireque Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation European Medical Journal cryopreservation lipid metabolism lipid profile mass spectrometry oocyte |
| title | Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation |
| title_full | Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation |
| title_fullStr | Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation |
| title_full_unstemmed | Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation |
| title_short | Updating the Impact of Lipid Metabolism Modulation and Lipidomic Profiling on Oocyte Cryopreservation |
| title_sort | updating the impact of lipid metabolism modulation and lipidomic profiling on oocyte cryopreservation |
| topic | cryopreservation lipid metabolism lipid profile mass spectrometry oocyte |
| url | https://www.emjreviews.com/reproductive-health/article/updating-the-impact-of-lipid-metabolism-modulation-and-lipidomic-profiling-on-oocyte-cryopreservation/ |
| work_keys_str_mv | AT eduardodomingosborges updatingtheimpactoflipidmetabolismmodulationandlipidomicprofilingonoocytecryopreservation AT alessandraaparecidavireque updatingtheimpactoflipidmetabolismmodulationandlipidomicprofilingonoocytecryopreservation |