Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities
Manganese metallic nanoparticles are attractive materials for various biological and medical applications. In the present study, we synthesized unique Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>...
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| Format: | Article |
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MDPI AG
2019-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/9/11/1635 |
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| author | Sultan Akhtar Suriya Rehman Munirah A. Almessiere Firdos Alam Khan Yassine Slimani Abdulhadi Baykal |
| author_facet | Sultan Akhtar Suriya Rehman Munirah A. Almessiere Firdos Alam Khan Yassine Slimani Abdulhadi Baykal |
| author_sort | Sultan Akhtar |
| collection | DOAJ |
| description | Manganese metallic nanoparticles are attractive materials for various biological and medical applications. In the present study, we synthesized unique Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> (0.01 ≤ x ≤ 0.05) nanoparticles (NPs) by using the hydrothermal approach. The structure and surface morphology of the products were determined by X-ray powder diffraction (XRD), transmission electron and scanning electron microcopies (TEM and SEM), along with energy dispersive X-ray spectroscopy (EDX). We evaluated the impact of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> NPs on both human embryonic stem cells (HEK-293) (normal cells) and human colon carcinoma cells (HCT-116) (cancerous cells). We found that post-48 h of treatment of all products showed a significant decline in the cancer cell population as revealed by microscopically and the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium (MTT) assay. The inhibitory concentration (IC<sub>50</sub>) values of the products ranged between 0.75 and 2.25 µg/mL. When tested on normal and healthy cells (HEK-293), we found that the treatment of products did not produce any effects on the normal cells, which suggests that all products selectively targeted the cancerous cells. The anti-bacterial properties of the samples were also evaluated by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays, which showed that products also inhibited the bacterial growth. |
| first_indexed | 2024-12-22T10:38:17Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-22T10:38:17Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-9e22de2fe881431b8ec2abc273c9f5002022-12-21T18:29:07ZengMDPI AGNanomaterials2079-49912019-11-01911163510.3390/nano9111635nano9111635Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial ActivitiesSultan Akhtar0Suriya Rehman1Munirah A. Almessiere2Firdos Alam Khan3Yassine Slimani4Abdulhadi Baykal5Department of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Stem Cell Biology, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Post Box No. 1982, Dammam 31441, Saudi ArabiaDepartment of Biophysics, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Nano-Medicine Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.0. Box 1982, Dammam 31441, Saudi ArabiaManganese metallic nanoparticles are attractive materials for various biological and medical applications. In the present study, we synthesized unique Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> (0.01 ≤ x ≤ 0.05) nanoparticles (NPs) by using the hydrothermal approach. The structure and surface morphology of the products were determined by X-ray powder diffraction (XRD), transmission electron and scanning electron microcopies (TEM and SEM), along with energy dispersive X-ray spectroscopy (EDX). We evaluated the impact of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> NPs on both human embryonic stem cells (HEK-293) (normal cells) and human colon carcinoma cells (HCT-116) (cancerous cells). We found that post-48 h of treatment of all products showed a significant decline in the cancer cell population as revealed by microscopically and the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium (MTT) assay. The inhibitory concentration (IC<sub>50</sub>) values of the products ranged between 0.75 and 2.25 µg/mL. When tested on normal and healthy cells (HEK-293), we found that the treatment of products did not produce any effects on the normal cells, which suggests that all products selectively targeted the cancerous cells. The anti-bacterial properties of the samples were also evaluated by Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) assays, which showed that products also inhibited the bacterial growth.https://www.mdpi.com/2079-4991/9/11/1635spinel ferritescytotoxicityantibacterial activityhydrothermal synthesis |
| spellingShingle | Sultan Akhtar Suriya Rehman Munirah A. Almessiere Firdos Alam Khan Yassine Slimani Abdulhadi Baykal Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities Nanomaterials spinel ferrites cytotoxicity antibacterial activity hydrothermal synthesis |
| title | Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities |
| title_full | Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities |
| title_fullStr | Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities |
| title_full_unstemmed | Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities |
| title_short | Synthesis of Mn<sub>0.5</sub>Zn<sub>0.5</sub>Sm<sub>x</sub>Eu<sub>x</sub>Fe<sub>1.8−2x</sub>O<sub>4</sub> Nanoparticles via the Hydrothermal Approach Induced Anti-Cancer and Anti-Bacterial Activities |
| title_sort | synthesis of mn sub 0 5 sub zn sub 0 5 sub sm sub x sub eu sub x sub fe sub 1 8 2x sub o sub 4 sub nanoparticles via the hydrothermal approach induced anti cancer and anti bacterial activities |
| topic | spinel ferrites cytotoxicity antibacterial activity hydrothermal synthesis |
| url | https://www.mdpi.com/2079-4991/9/11/1635 |
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