Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma
Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23). Maxillofacial tumors are rarely involved in TIO, especially maxillary TIO in children. We present a 14-year-old boy with osteomalacia a...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2023-12-01
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| Series: | JCRPE |
| Subjects: | |
| Online Access: | https://jcrpe.org/jvi.aspx?un=JCRPE-78941&volume=15&issue=4 |
| _version_ | 1797449578224549888 |
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| author | Ha Nguyen Thi Cuong Pham Manh Linh To Tuan Lan Anh Le Thi Nam Nguyen Thanh Soamarat Vilaiyuk |
| author_facet | Ha Nguyen Thi Cuong Pham Manh Linh To Tuan Lan Anh Le Thi Nam Nguyen Thanh Soamarat Vilaiyuk |
| author_sort | Ha Nguyen Thi |
| collection | DOAJ |
| description | Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23). Maxillofacial tumors are rarely involved in TIO, especially maxillary TIO in children. We present a 14-year-old boy with osteomalacia and high serum levels of FGF23, a hormone associated with decreased phosphate resorption, due to a maxillary tumor. The patient was treated with oral phosphorus and calcitriol, and surgical removal of the tumor was performed. After 21 months follow-up, he was pain free and had returned to full activity. We review the reported pediatric cases of TIO in the maxillofacial and oral region and discuss the management of these patients considering the published evidence. |
| first_indexed | 2024-03-09T14:27:03Z |
| format | Article |
| id | doaj.art-9e23d77a3b0a4dcdac7b8df2ae41feb9 |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-03-09T14:27:03Z |
| publishDate | 2023-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-9e23d77a3b0a4dcdac7b8df2ae41feb92023-11-28T07:05:32ZengGalenos YayincilikJCRPE1308-57271308-57352023-12-0115442142510.4274/jcrpe.galenos.2022.2021-8-14Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying FibromaHa Nguyen Thi0https://orcid.org/0000-0003-0467-2499Cuong Pham Manh1https://orcid.org/0000-0001-5358-4642Linh To Tuan2https://orcid.org/0000-0003-3609-4814Lan Anh Le Thi3https://orcid.org/0000-0002-8268-7912Nam Nguyen Thanh4https://orcid.org/0000-0002-7622-7530Soamarat Vilaiyuk5https://orcid.org/0000-0003-2331-9711Hanoi Medical University, Bach Mai Hospital, Clinic of Pediatrics, Hanoi, VietnamBach Mai Hospital, Diagnostic Imaging Central, Hanoi, VietnamViet Duc Hospital, Maxillofacial, Department of Plastic and Aesthetic Surgery, Hanoi, VietnamHanoi Medical University, Bach Mai Hospital, Clinic of Pediatrics, Hanoi, VietnamBach Mai Hospital, Clinic of Pediatrics, Hanoi, VietnamMahidol University Faculty of Medicine; Ramathibodi Hospital, Department of Pediatrics, Division of Rheumatology, Bangkok, ThailandTumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23). Maxillofacial tumors are rarely involved in TIO, especially maxillary TIO in children. We present a 14-year-old boy with osteomalacia and high serum levels of FGF23, a hormone associated with decreased phosphate resorption, due to a maxillary tumor. The patient was treated with oral phosphorus and calcitriol, and surgical removal of the tumor was performed. After 21 months follow-up, he was pain free and had returned to full activity. We review the reported pediatric cases of TIO in the maxillofacial and oral region and discuss the management of these patients considering the published evidence.https://jcrpe.org/jvi.aspx?un=JCRPE-78941&volume=15&issue=4tumor-induced osteomalaciafibroblast growth factor-23maxillachildren |
| spellingShingle | Ha Nguyen Thi Cuong Pham Manh Linh To Tuan Lan Anh Le Thi Nam Nguyen Thanh Soamarat Vilaiyuk Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma JCRPE tumor-induced osteomalacia fibroblast growth factor-23 maxilla children |
| title | Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma |
| title_full | Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma |
| title_fullStr | Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma |
| title_full_unstemmed | Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma |
| title_short | Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma |
| title_sort | tumor induced osteomalacia in a boy with maxillary ossifying fibroma |
| topic | tumor-induced osteomalacia fibroblast growth factor-23 maxilla children |
| url | https://jcrpe.org/jvi.aspx?un=JCRPE-78941&volume=15&issue=4 |
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