The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond
There are currently no promising therapy strategies for either the treatment or prevention of novel coronavirus disease 2019 (COVID-19), despite the urgent need. In addition to respiratory diseases, vascular complications are rapidly emerging as a key threat of COVID-19. Existing nitric oxide (NO) t...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/9/1699 |
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| author | Tomohiro Akiyama Takamichi Hirata Takahiro Fujimoto Shinnosuke Hatakeyama Ryuhei Yamazaki Tomohiro Nomura |
| author_facet | Tomohiro Akiyama Takamichi Hirata Takahiro Fujimoto Shinnosuke Hatakeyama Ryuhei Yamazaki Tomohiro Nomura |
| author_sort | Tomohiro Akiyama |
| collection | DOAJ |
| description | There are currently no promising therapy strategies for either the treatment or prevention of novel coronavirus disease 2019 (COVID-19), despite the urgent need. In addition to respiratory diseases, vascular complications are rapidly emerging as a key threat of COVID-19. Existing nitric oxide (NO) therapies have been shown to improve the vascular system; however, they have different limitations in terms of safety, usability and availability. In light of this, we hypothesise that a natural-mineral-based novel nanomaterial, which was developed based on NO therapy, might be a viable strategy for the treatment and prevention of COVID-19. The present study examined if it could induce an increase of intravascular NO, vasodilation and the consequent increase of blood flow rate and temperature in a living body. The intravascular NO concentration in the hepatic portal of rats was increased by 0.17 nM over 35.2 s on average after its application. An ultrasonic Doppler flow meter showed significant increases in the blood flow rate and vessel diameter, but no difference in the blood flow velocity. These were corroborated by measurements of human hand surface temperature. To our knowledge, this result is the first evidence where an increase of intravascular NO and vasodilation were induced by bringing a natural-mineral-based nanomaterial into contact with or close to a living body. The precise mechanisms remain a matter for further investigation; however, we may assume that endothelial NO synthase, haemoglobin and endothelium-derived hyperpolarising factor are deeply involved in the increase of intravascular NO. |
| first_indexed | 2024-03-10T16:44:03Z |
| format | Article |
| id | doaj.art-9e28c029e9094461a2cdbf6eb769d36c |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T16:44:03Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-9e28c029e9094461a2cdbf6eb769d36c2023-11-20T11:48:04ZengMDPI AGNanomaterials2079-49912020-08-01109169910.3390/nano10091699The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyondTomohiro Akiyama0Takamichi Hirata1Takahiro Fujimoto2Shinnosuke Hatakeyama3Ryuhei Yamazaki4Tomohiro Nomura5Advanced Research Laboratories, Tokyo City University, Tokyo 158-8557, JapanAdvanced Research Laboratories, Tokyo City University, Tokyo 158-8557, JapanAdvanced Research Laboratories, Tokyo City University, Tokyo 158-8557, JapanGraduate School of Integrative Science and Engineering, Electrical Engineering and Chemistry, Tokyo City University, Tokyo 158-8557, JapanGraduate School of Integrative Science and Engineering, Electrical Engineering and Chemistry, Tokyo City University, Tokyo 158-8557, JapanOsaka City University, Osaka 558-8585, JapanThere are currently no promising therapy strategies for either the treatment or prevention of novel coronavirus disease 2019 (COVID-19), despite the urgent need. In addition to respiratory diseases, vascular complications are rapidly emerging as a key threat of COVID-19. Existing nitric oxide (NO) therapies have been shown to improve the vascular system; however, they have different limitations in terms of safety, usability and availability. In light of this, we hypothesise that a natural-mineral-based novel nanomaterial, which was developed based on NO therapy, might be a viable strategy for the treatment and prevention of COVID-19. The present study examined if it could induce an increase of intravascular NO, vasodilation and the consequent increase of blood flow rate and temperature in a living body. The intravascular NO concentration in the hepatic portal of rats was increased by 0.17 nM over 35.2 s on average after its application. An ultrasonic Doppler flow meter showed significant increases in the blood flow rate and vessel diameter, but no difference in the blood flow velocity. These were corroborated by measurements of human hand surface temperature. To our knowledge, this result is the first evidence where an increase of intravascular NO and vasodilation were induced by bringing a natural-mineral-based nanomaterial into contact with or close to a living body. The precise mechanisms remain a matter for further investigation; however, we may assume that endothelial NO synthase, haemoglobin and endothelium-derived hyperpolarising factor are deeply involved in the increase of intravascular NO.https://www.mdpi.com/2079-4991/10/9/1699SARS-CoV-2COVID-19natural-mineral-based nanomaterialnitric oxidehaemoglobinblood flow promotion |
| spellingShingle | Tomohiro Akiyama Takamichi Hirata Takahiro Fujimoto Shinnosuke Hatakeyama Ryuhei Yamazaki Tomohiro Nomura The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond Nanomaterials SARS-CoV-2 COVID-19 natural-mineral-based nanomaterial nitric oxide haemoglobin blood flow promotion |
| title | The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond |
| title_full | The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond |
| title_fullStr | The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond |
| title_full_unstemmed | The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond |
| title_short | The Natural-Mineral-Based Novel Nanomaterial IFMC Increases Intravascular Nitric Oxide without Its Intake: Implications for COVID-19 and beyond |
| title_sort | natural mineral based novel nanomaterial ifmc increases intravascular nitric oxide without its intake implications for covid 19 and beyond |
| topic | SARS-CoV-2 COVID-19 natural-mineral-based nanomaterial nitric oxide haemoglobin blood flow promotion |
| url | https://www.mdpi.com/2079-4991/10/9/1699 |
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