Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development

Analytical and Computational Methods for the Estimation of Drug-Polymer Solubility and Miscibility in Solid Dispersions Development

The development of stable solid dispersion formulations that maintain desired improvement of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer solubility and miscibility. Only if the drug concentration is below the solubility limit in the polymer, the physical...

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Bibliographic Details
Main Authors: Djordje Medarević, Jelena Djuriš, Panagiotis Barmpalexis, Kyriakos Kachrimanis, Svetlana Ibrić
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
solid dispersions
miscibility
solubility
thermodynamic modeling
phase diagram
molecular dynamics simulation
thermal analysis
spectroscopic techniques
Online Access:https://www.mdpi.com/1999-4923/11/8/372

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