Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns.
The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the matur...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-11-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2071944?pdf=render |
| _version_ | 1818618172684632064 |
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| author | Wolfgang Kelsch Colleen P Mosley Chia-Wei Lin Carlos Lois |
| author_facet | Wolfgang Kelsch Colleen P Mosley Chia-Wei Lin Carlos Lois |
| author_sort | Wolfgang Kelsch |
| collection | DOAJ |
| description | The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit or by cell-autonomous properties of the immature neurons, already determined by their precursors. Using retroviral fate mapping, we studied the lamina-specific dendritic targeting of one neuronal type as defined by its morphology and intrinsic somatic electrical properties in neonatal and adult neurogenesis. Fate mapping revealed the existence of two separate populations of neuronal precursors that gave rise to the same neuronal type with two distinct patterns of dendritic targeting-innervating either a deep or superficial lamina, where they connect to different types of principal neurons. Furthermore, heterochronic and heterotopic transplantation demonstrated that these precursors were largely restricted to generate neurons with a predetermined pattern of dendritic targeting that was independent of the host environment. Our results demonstrate that, at least in the neonatal and adult mammalian brain, the pattern of dendritic targeting of a given neuron is a cell-autonomous property of their precursors. |
| first_indexed | 2024-12-16T17:17:22Z |
| format | Article |
| id | doaj.art-9e2cf8b981e54e77941176888129036d |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-16T17:17:22Z |
| publishDate | 2007-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-9e2cf8b981e54e77941176888129036d2022-12-21T22:23:16ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852007-11-01511e30010.1371/journal.pbio.0050300Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns.Wolfgang KelschColleen P MosleyChia-Wei LinCarlos LoisThe mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type-specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit or by cell-autonomous properties of the immature neurons, already determined by their precursors. Using retroviral fate mapping, we studied the lamina-specific dendritic targeting of one neuronal type as defined by its morphology and intrinsic somatic electrical properties in neonatal and adult neurogenesis. Fate mapping revealed the existence of two separate populations of neuronal precursors that gave rise to the same neuronal type with two distinct patterns of dendritic targeting-innervating either a deep or superficial lamina, where they connect to different types of principal neurons. Furthermore, heterochronic and heterotopic transplantation demonstrated that these precursors were largely restricted to generate neurons with a predetermined pattern of dendritic targeting that was independent of the host environment. Our results demonstrate that, at least in the neonatal and adult mammalian brain, the pattern of dendritic targeting of a given neuron is a cell-autonomous property of their precursors.http://europepmc.org/articles/PMC2071944?pdf=render |
| spellingShingle | Wolfgang Kelsch Colleen P Mosley Chia-Wei Lin Carlos Lois Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. PLoS Biology |
| title | Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. |
| title_full | Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. |
| title_fullStr | Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. |
| title_full_unstemmed | Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. |
| title_short | Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns. |
| title_sort | distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns |
| url | http://europepmc.org/articles/PMC2071944?pdf=render |
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