Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations
Spatially remote brain regions exhibit dynamic functional interactions across various task conditions. While time-varying functional connectivity during movie watching shows sensitivity to movie content, stationary functional connectivity remains relatively stable across videos. These findings sugge...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000853 |
| _version_ | 1797671481143984128 |
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| author | Xin Di Ting Xu Lucina Q. Uddin Bharat B. Biswal |
| author_facet | Xin Di Ting Xu Lucina Q. Uddin Bharat B. Biswal |
| author_sort | Xin Di |
| collection | DOAJ |
| description | Spatially remote brain regions exhibit dynamic functional interactions across various task conditions. While time-varying functional connectivity during movie watching shows sensitivity to movie content, stationary functional connectivity remains relatively stable across videos. These findings suggest that dynamic and stationary functional interactions may represent different aspects of brain function. However, the relationship between individual differences in time-varying and stationary connectivity and behavioral phenotypes remains elusive. To address this gap, we analyzed an open-access functional MRI dataset comprising participants aged 5–22 years, who watched two cartoon movie clips. We calculated regional brain activity, time-varying connectivity, and stationary connectivity, examining associations with age, sex, and behavioral assessments. Model comparison revealed that time-varying connectivity was more sensitive to age and sex effects compared with stationary connectivity. The preferred age models exhibited quadratic log age or quadratic age effects, indicative of inverted-U shaped developmental patterns. In addition, females showed higher consistency in regional brain activity and time-varying connectivity than males. However, in terms of behavioral predictions, only stationary connectivity demonstrated the ability to predict full-scale intelligence quotient. These findings suggest that individual differences in time-varying and stationary connectivity may capture distinct aspects of behavioral phenotypes. |
| first_indexed | 2024-03-11T21:15:09Z |
| format | Article |
| id | doaj.art-9e2d2c9ceec4437ba55694427040e640 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-11T21:15:09Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-9e2d2c9ceec4437ba55694427040e6402023-09-29T04:43:57ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-10-0163101280Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associationsXin Di0Ting Xu1Lucina Q. Uddin2Bharat B. Biswal3Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA; Correspondence to: 604 Fenster Hall, University Height, Newark, NJ 07102, USA.Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USADepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA 90095, USADepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA; Correspondence to: 607 Fenster Hall, University Height, Newark, NJ 07102, USA.Spatially remote brain regions exhibit dynamic functional interactions across various task conditions. While time-varying functional connectivity during movie watching shows sensitivity to movie content, stationary functional connectivity remains relatively stable across videos. These findings suggest that dynamic and stationary functional interactions may represent different aspects of brain function. However, the relationship between individual differences in time-varying and stationary connectivity and behavioral phenotypes remains elusive. To address this gap, we analyzed an open-access functional MRI dataset comprising participants aged 5–22 years, who watched two cartoon movie clips. We calculated regional brain activity, time-varying connectivity, and stationary connectivity, examining associations with age, sex, and behavioral assessments. Model comparison revealed that time-varying connectivity was more sensitive to age and sex effects compared with stationary connectivity. The preferred age models exhibited quadratic log age or quadratic age effects, indicative of inverted-U shaped developmental patterns. In addition, females showed higher consistency in regional brain activity and time-varying connectivity than males. However, in terms of behavioral predictions, only stationary connectivity demonstrated the ability to predict full-scale intelligence quotient. These findings suggest that individual differences in time-varying and stationary connectivity may capture distinct aspects of behavioral phenotypes.http://www.sciencedirect.com/science/article/pii/S1878929323000853Brain connectivityBrain developmentModel comparisonMovie watchingTime-varying connectivity |
| spellingShingle | Xin Di Ting Xu Lucina Q. Uddin Bharat B. Biswal Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations Developmental Cognitive Neuroscience Brain connectivity Brain development Model comparison Movie watching Time-varying connectivity |
| title | Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations |
| title_full | Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations |
| title_fullStr | Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations |
| title_full_unstemmed | Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations |
| title_short | Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations |
| title_sort | individual differences in time varying and stationary brain connectivity during movie watching from childhood to early adulthood age sex and behavioral associations |
| topic | Brain connectivity Brain development Model comparison Movie watching Time-varying connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000853 |
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