Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
Abstract Background Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear. Methods Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (G...
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BMC
2023-01-01
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Series: | BMC Pulmonary Medicine |
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Online Access: | https://doi.org/10.1186/s12890-022-02297-0 |
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author | Xiuqing Wang Xiulan Wang Hongkang Wang Mingxing Yang Wen Dong Dan Shao |
author_facet | Xiuqing Wang Xiulan Wang Hongkang Wang Mingxing Yang Wen Dong Dan Shao |
author_sort | Xiuqing Wang |
collection | DOAJ |
description | Abstract Background Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear. Methods Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (GWAS). Genetic information of lung cancer was retrieved from GWAS of International Lung Cancer Consortium. A set of quality control steps were conducted to select instrumental tools. We performed two independent two-sample Mendelian randomization (MR) analyses and a meta-analysis based on the two independent MR estimates to assess the causal relationship between psoriasis and lung cancer (LUCA) as well as its subtypes, squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD). Results Between-SNP heterogeneity was present for most MR analyses, whereas horizontal pleiotropy was not detected for all MR analyses. Multiplicative random-effect inverse variance weighted (IVW-MRE) method was therefore selected as the primary MR approach. Both IVW-MRE estimates from the two independent MR analyses suggested that there was no significant causal relationship between psoriasis and LUCA as well as its histological subtypes. Sensitivity analyses using other four MR methods gave similar results. Meta-analysis of the two IVW-MRE derived MR estimates yielded an odds ratio (OR) of 1.00 (95% CI 0.95–1.06) for LUCA, 1.01 (95% CI 0.93–1.08) for LUSC, and 0.97 (95% CI 0.90–1.06) for LUAD. Conclusion Our results do not support a genetic association between psoriasis and lung cancer and its subtypes. More population-based and experimental studies are warranted to further dissect the complex correlation between psoriasis and lung cancer. |
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issn | 1471-2466 |
language | English |
last_indexed | 2024-04-11T00:25:16Z |
publishDate | 2023-01-01 |
publisher | BMC |
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series | BMC Pulmonary Medicine |
spelling | doaj.art-9e2f517e79c44ffaaee5fc8385e26dc32023-01-08T12:04:03ZengBMCBMC Pulmonary Medicine1471-24662023-01-012311910.1186/s12890-022-02297-0Association between psoriasis and lung cancer: two-sample Mendelian randomization analysesXiuqing Wang0Xiulan Wang1Hongkang Wang2Mingxing Yang3Wen Dong4Dan Shao5Department of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory Medicine, Hainan Provincial Hospital of Chinese MedicineDepartment of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory and Critical Care Medicine, Inner Mongolia Xing’an Meng People’s HospitalAbstract Background Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear. Methods Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (GWAS). Genetic information of lung cancer was retrieved from GWAS of International Lung Cancer Consortium. A set of quality control steps were conducted to select instrumental tools. We performed two independent two-sample Mendelian randomization (MR) analyses and a meta-analysis based on the two independent MR estimates to assess the causal relationship between psoriasis and lung cancer (LUCA) as well as its subtypes, squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD). Results Between-SNP heterogeneity was present for most MR analyses, whereas horizontal pleiotropy was not detected for all MR analyses. Multiplicative random-effect inverse variance weighted (IVW-MRE) method was therefore selected as the primary MR approach. Both IVW-MRE estimates from the two independent MR analyses suggested that there was no significant causal relationship between psoriasis and LUCA as well as its histological subtypes. Sensitivity analyses using other four MR methods gave similar results. Meta-analysis of the two IVW-MRE derived MR estimates yielded an odds ratio (OR) of 1.00 (95% CI 0.95–1.06) for LUCA, 1.01 (95% CI 0.93–1.08) for LUSC, and 0.97 (95% CI 0.90–1.06) for LUAD. Conclusion Our results do not support a genetic association between psoriasis and lung cancer and its subtypes. More population-based and experimental studies are warranted to further dissect the complex correlation between psoriasis and lung cancer.https://doi.org/10.1186/s12890-022-02297-0Lung cancerPsoriasisMendelian randomizationSmokingGenetics |
spellingShingle | Xiuqing Wang Xiulan Wang Hongkang Wang Mingxing Yang Wen Dong Dan Shao Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses BMC Pulmonary Medicine Lung cancer Psoriasis Mendelian randomization Smoking Genetics |
title | Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses |
title_full | Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses |
title_fullStr | Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses |
title_full_unstemmed | Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses |
title_short | Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses |
title_sort | association between psoriasis and lung cancer two sample mendelian randomization analyses |
topic | Lung cancer Psoriasis Mendelian randomization Smoking Genetics |
url | https://doi.org/10.1186/s12890-022-02297-0 |
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