Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses

Abstract Background Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear. Methods Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (G...

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Main Authors: Xiuqing Wang, Xiulan Wang, Hongkang Wang, Mingxing Yang, Wen Dong, Dan Shao
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Pulmonary Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12890-022-02297-0
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author Xiuqing Wang
Xiulan Wang
Hongkang Wang
Mingxing Yang
Wen Dong
Dan Shao
author_facet Xiuqing Wang
Xiulan Wang
Hongkang Wang
Mingxing Yang
Wen Dong
Dan Shao
author_sort Xiuqing Wang
collection DOAJ
description Abstract Background Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear. Methods Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (GWAS). Genetic information of lung cancer was retrieved from GWAS of International Lung Cancer Consortium. A set of quality control steps were conducted to select instrumental tools. We performed two independent two-sample Mendelian randomization (MR) analyses and a meta-analysis based on the two independent MR estimates to assess the causal relationship between psoriasis and lung cancer (LUCA) as well as its subtypes, squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD). Results Between-SNP heterogeneity was present for most MR analyses, whereas horizontal pleiotropy was not detected for all MR analyses. Multiplicative random-effect inverse variance weighted (IVW-MRE) method was therefore selected as the primary MR approach. Both IVW-MRE estimates from the two independent MR analyses suggested that there was no significant causal relationship between psoriasis and LUCA as well as its histological subtypes. Sensitivity analyses using other four MR methods gave similar results. Meta-analysis of the two IVW-MRE derived MR estimates yielded an odds ratio (OR) of 1.00 (95% CI 0.95–1.06) for LUCA, 1.01 (95% CI 0.93–1.08) for LUSC, and 0.97 (95% CI 0.90–1.06) for LUAD. Conclusion Our results do not support a genetic association between psoriasis and lung cancer and its subtypes. More population-based and experimental studies are warranted to further dissect the complex correlation between psoriasis and lung cancer.
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spelling doaj.art-9e2f517e79c44ffaaee5fc8385e26dc32023-01-08T12:04:03ZengBMCBMC Pulmonary Medicine1471-24662023-01-012311910.1186/s12890-022-02297-0Association between psoriasis and lung cancer: two-sample Mendelian randomization analysesXiuqing Wang0Xiulan Wang1Hongkang Wang2Mingxing Yang3Wen Dong4Dan Shao5Department of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory Medicine, Hainan Provincial Hospital of Chinese MedicineDepartment of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory Medicine, Hainan Cancer HospitalDepartment of Respiratory and Critical Care Medicine, Inner Mongolia Xing’an Meng People’s HospitalAbstract Background Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear. Methods Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (GWAS). Genetic information of lung cancer was retrieved from GWAS of International Lung Cancer Consortium. A set of quality control steps were conducted to select instrumental tools. We performed two independent two-sample Mendelian randomization (MR) analyses and a meta-analysis based on the two independent MR estimates to assess the causal relationship between psoriasis and lung cancer (LUCA) as well as its subtypes, squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD). Results Between-SNP heterogeneity was present for most MR analyses, whereas horizontal pleiotropy was not detected for all MR analyses. Multiplicative random-effect inverse variance weighted (IVW-MRE) method was therefore selected as the primary MR approach. Both IVW-MRE estimates from the two independent MR analyses suggested that there was no significant causal relationship between psoriasis and LUCA as well as its histological subtypes. Sensitivity analyses using other four MR methods gave similar results. Meta-analysis of the two IVW-MRE derived MR estimates yielded an odds ratio (OR) of 1.00 (95% CI 0.95–1.06) for LUCA, 1.01 (95% CI 0.93–1.08) for LUSC, and 0.97 (95% CI 0.90–1.06) for LUAD. Conclusion Our results do not support a genetic association between psoriasis and lung cancer and its subtypes. More population-based and experimental studies are warranted to further dissect the complex correlation between psoriasis and lung cancer.https://doi.org/10.1186/s12890-022-02297-0Lung cancerPsoriasisMendelian randomizationSmokingGenetics
spellingShingle Xiuqing Wang
Xiulan Wang
Hongkang Wang
Mingxing Yang
Wen Dong
Dan Shao
Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
BMC Pulmonary Medicine
Lung cancer
Psoriasis
Mendelian randomization
Smoking
Genetics
title Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
title_full Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
title_fullStr Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
title_full_unstemmed Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
title_short Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses
title_sort association between psoriasis and lung cancer two sample mendelian randomization analyses
topic Lung cancer
Psoriasis
Mendelian randomization
Smoking
Genetics
url https://doi.org/10.1186/s12890-022-02297-0
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AT mingxingyang associationbetweenpsoriasisandlungcancertwosamplemendelianrandomizationanalyses
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