AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery

AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery

Adeno-associated virus (AAV) is one of the most commonly used vectors for gene therapy, and the applications for AAV-delivered therapies are numerous. However, the current state of technology is limited by the low efficiency with which most AAV vectors transduce skeletal muscle tissue. We demonstrat...

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Bibliographic Details
Main Authors: Cody B. Jackson, Audrey S. Richard, Amrita Ojha, Kimberly A. Conkright, Jeffrey M. Trimarchi, Charles C. Bailey, Michael D. Alpert, Mark A. Kay, Michael Farzan, Hyeryun Choe
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vector engineering
gene therapy
skeletal muscle
insulin receptor
adeno-associated virus
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012030231X

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http://www.sciencedirect.com/science/article/pii/S232905012030231X

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