Cognitive bias in rats is not influenced by oxytocin
The effect of oxytocin on cognitive bias was investigated in rats in a modified conditioned place preference (CPP) paradigm. Fifteen male rats were trained to discriminate between two different cue combinations, one paired with palatable foods (reward training), and the other paired with unpalatable...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-09-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01306/full |
| _version_ | 1819102919496040448 |
|---|---|
| author | Molly C McGuire Keith L. Williams Lisa L Welling Jennifer eVonk |
| author_facet | Molly C McGuire Keith L. Williams Lisa L Welling Jennifer eVonk |
| author_sort | Molly C McGuire |
| collection | DOAJ |
| description | The effect of oxytocin on cognitive bias was investigated in rats in a modified conditioned place preference (CPP) paradigm. Fifteen male rats were trained to discriminate between two different cue combinations, one paired with palatable foods (reward training), and the other paired with unpalatable food (aversive training). Next, their reactions to two ambiguous cue combinations were evaluated and their latency to contact the goal pot recorded. Rats were injected with either oxytocin (OT) or saline with the prediction that rats administered oxytocin would display a shorter average latency to approach on ambiguous trials. There was no significant difference between latencies to approach on ambiguous trials compared to reward trials, but the rats were significantly slower on the aversive compared to the ambiguous conditions. Oxytocin did not affect approach time; however, it was unclear, after follow-up testing, whether the OT doses tested were sufficient to produce the desired effects on cognitive bias. Future research should consider this possibility. |
| first_indexed | 2024-12-22T01:42:13Z |
| format | Article |
| id | doaj.art-9e31a82db8e946f2bbc8eb79c2b334ab |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-22T01:42:13Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-9e31a82db8e946f2bbc8eb79c2b334ab2022-12-21T18:43:10ZengFrontiers Media S.A.Frontiers in Psychology1664-10782015-09-01610.3389/fpsyg.2015.01306152615Cognitive bias in rats is not influenced by oxytocinMolly C McGuire0Keith L. Williams1Lisa L Welling2Jennifer eVonk3Oakland UniversityOakland UniversityOakland UniversityOakland UniversityThe effect of oxytocin on cognitive bias was investigated in rats in a modified conditioned place preference (CPP) paradigm. Fifteen male rats were trained to discriminate between two different cue combinations, one paired with palatable foods (reward training), and the other paired with unpalatable food (aversive training). Next, their reactions to two ambiguous cue combinations were evaluated and their latency to contact the goal pot recorded. Rats were injected with either oxytocin (OT) or saline with the prediction that rats administered oxytocin would display a shorter average latency to approach on ambiguous trials. There was no significant difference between latencies to approach on ambiguous trials compared to reward trials, but the rats were significantly slower on the aversive compared to the ambiguous conditions. Oxytocin did not affect approach time; however, it was unclear, after follow-up testing, whether the OT doses tested were sufficient to produce the desired effects on cognitive bias. Future research should consider this possibility.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01306/fullOxytocinRatscognitive biasPlace PreferenceAmbiguous cueapproach latency. |
| spellingShingle | Molly C McGuire Keith L. Williams Lisa L Welling Jennifer eVonk Cognitive bias in rats is not influenced by oxytocin Frontiers in Psychology Oxytocin Rats cognitive bias Place Preference Ambiguous cue approach latency. |
| title | Cognitive bias in rats is not influenced by oxytocin |
| title_full | Cognitive bias in rats is not influenced by oxytocin |
| title_fullStr | Cognitive bias in rats is not influenced by oxytocin |
| title_full_unstemmed | Cognitive bias in rats is not influenced by oxytocin |
| title_short | Cognitive bias in rats is not influenced by oxytocin |
| title_sort | cognitive bias in rats is not influenced by oxytocin |
| topic | Oxytocin Rats cognitive bias Place Preference Ambiguous cue approach latency. |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2015.01306/full |
| work_keys_str_mv | AT mollycmcguire cognitivebiasinratsisnotinfluencedbyoxytocin AT keithlwilliams cognitivebiasinratsisnotinfluencedbyoxytocin AT lisalwelling cognitivebiasinratsisnotinfluencedbyoxytocin AT jenniferevonk cognitivebiasinratsisnotinfluencedbyoxytocin |