Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responses

Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responses

Encouraging protection results from current mRNA-based SARS-CoV-2 vaccine platforms are primarily due to the induction of SARS- CoV-2- specific B cell antibody and CD4 + T cell. Even though, current mRNA vaccine platforms are adept in inducing SARS-CoV2-specific CD8 + T cell, much less is known abou...

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Bibliographic Details
Main Authors: Laura Padula, Eva Fisher, Katelyn Rivas, Kristin Podack, Daniela Frasca, Jonah Kupritz, Matthew M. Seavey, Padmini Jayaraman, Eric Dixon, Rahul Jasuja, Natasa Strbo
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Vaccine: X
Subjects:
OX40L
Heat shock protein
Gp96
Vaccine
SARS-CoV-2 protein S
B cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136222000626

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