Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT

Standard threshold laser versus subthreshold micropulse laser for adults with diabetic macular oedema: the DIAMONDS non-inferiority RCT

Background: The National Institute for Health and Care Excellence recommends macular laser to treat diabetic macular oedema with a central retinal subfield thickness of < 400 µm on optical coherence tomography. The DIAMONDS (DIAbetic Macular Oedema aNd Diode Subthreshold micropulse laser) trial c...

Full description

Bibliographic Details
Main Authors:	Noemi Lois, Christina Campbell, Norman Waugh, Augusto Azuara-Blanco, Mandy Maredza, Hema Mistry, Danny McAuley, Nachiketa Acharya, Tariq M Aslam, Clare Bailey, Victor Chong, Louise Downey, Haralabos Eleftheriadis, Samia Fatum, Sheena George, Faruque Ghanchi, Markus Groppe, Robin Hamilton, Geeta Menon, Ahmed Saad, Sobha Sivaprasad, Marianne Shiew, David H Steel, James Stephen Talks, Paul Doherty, Clíona McDowell, Mike Clarke
Format:	Article
Language:	English
Published:	NIHR Journals Library 2022-12-01
Series:	Health Technology Assessment
Subjects:	diabetic macular edema dme diabetic macular oedema dmo diabetes laser micropulse subthreshold laser photocoagulation randomised clinical trial rct vascular endothelial growth factor vegf anti-vegfs ranibizumab aflibercept bevacizumab steroids cost-effectiveness eq5d-5l eq5d visqol nei vfq25 qol quality of life
Online Access:	https://doi.org/10.3310/SZKI2484

Similar Items

Comparison of micropulse subthreshold laser plus anti-VEGF versus anti-VEGF alone in diabetic macular edema: Systematic review
by: Parangeni M Lubis, et al.
Published: (2023-01-01)

Comparing the effectiveness of brolucizumab therapy alone versus that combined with subthreshold micropulse laser exposure in the treatment of diabetic macular edema
by: AO Giyasova, et al.
Published: (2023-04-01)

Measuring the quality of life of patients with diabetic retinopathy in northern India: a comparison of generic and vision specific instruments
by: Neha Purohit, et al.
Published: (2025-02-01)

Short-term Efficacy of Micropulse Yellow Laser in Non-center-involving Diabetic Macular Edema: Preliminary Results
by: Mehmet Fatih Kağan Değirmenci, et al.
Published: (2018-10-01)

Diabetic macular edema treatment with subthreshold micropulse laser - five-year long monitoring
by: Martina Zavorkova, et al.
Published: (2023-03-01)

Clinical Evaluation of Faricimab in Real-World Diabetic Macular Edema in India- A Multicenter Observational Study
by: Chakraborty D, et al.
Published: (2025-01-01)

Сlinical, functional and morphological results of diabetic macular edema antiangiogenic treatment in patients with diabetes mellitus type two
by: L. K. Moshetova, et al.
Published: (2014-07-01)

Evaluation Of Choroidal Thickness Before and After Intravitreal Injection Of Anti Vascular endothelial growth factors for Treatment Of Diabetic Macular Edema using Optical Coherence Tomography
by: Noha Mahmoud Ahmed Mohamed *, et al.
Published: (2023-07-01)

Micropulse Laser Therapy as an Integral Part of Eye Disease Management
by: Flaviu Bodea, et al.
Published: (2023-07-01)

Visual outcomes of observation, macular laser and anti-VEGF in diabetic macular edema in type 1 diabetes: a real-world study
by: Joonas Wirkkala, et al.
Published: (2022-06-01)

Role of inhibition of angiogenesis in patients with diabetic retinopathy
by: E.S. Chekhonin, et al.
Published: (2022-12-01)

Comparison of Subthreshold 532 nm Diode Micropulse Laser with Conventional Laser Photocoagulation in the Treatment of Non-Centre Involved Clinically Significant Diabetic Macular Edema
by: Panagiota Bougatsou, et al.
Published: (2020-01-01)

Efficacy & safety of brolucizumab 6.0 mg versus 3.6 mg in diabetic macular edema
by: Sanjay Kumar Mishra, et al.
Published: (2025-01-01)

Current and Novel Therapeutic Approaches for Treatment of Diabetic Macular Edema
by: Muhammad Z. Chauhan, et al.
Published: (2022-06-01)

Bibliometric and visualized analysis of diabetic macular edema
by: Jin Wei, et al.
Published: (2024-01-01)

Role of Microaneurysms in the Pathogenesis and Therapy of Diabetic Macular Edema: A Descriptive Review
by: Yoshihiro Takamura, et al.
Published: (2023-02-01)

Feasibility, acceptability and construct validity of EQ-5D in systemic sclerosis
by: Roberta Gualtierotti, et al.
Published: (2016-12-01)

Hubungan Kepatuhan Minum Obat terhadap HbA1C dan Kualitas Hidup Pasien Diabetes di RSI Purwodadi
by: Adi Fahmi Anshari, et al.
Published: (2023-12-01)

Health-related Quality of Life of Patients With Diabetes Mellitus Measured With the Bahasa Indonesia Version of EQ-5D in Primary Care Settings in Indonesia
by: Muhammad Husen Prabowo, et al.
Published: (2023-09-01)

Health-related quality of life in type-2 diabetes patients: a cross-sectional study in East China
by: You Lu, et al.
Published: (2017-07-01)

Short pulse grid and subthreshold micropulse laser (the sandwich grid) plus intravitreal ranibizumab for the treatment of diabetic macular edema
by: Renato Peroni, et al.
Published: (2024-09-01)

Pascal short-pulse plus subthreshold endpoint management laser therapy for diabetic macular edema: the “sandwich technique”
by: J. A. Cardillo, et al.
Published: (2022-06-01)

Assessment of Anti-VEGFs in Treating Diabetic Macular Edema in Alfaisal Eye Center, Khartoum, Sudan, 2019
by: Ahmedalgabri RHM, et al.
Published: (2022-04-01)

Transitioning from Aflibercept to Biosimilar Ranibizumab in Diabetic Macular Edema (DME): (The TRANSFORM-DME Trial) a Multicenter Observational Study
by: Chakraborty D, et al.
Published: (2024-11-01)

Modern view on the treatment of diabetic macular edema
by: A.V. Shelankova, et al.
Published: (2022-07-01)

Intravitreal Dexamethasone Implant in Anti-Vascular Endothelial Growth Factor Pretreated Diabetic Macular Edema—A Swiss Cohort Study
by: Ferhat Turgut, et al.
Published: (2024-09-01)

Association between renal function and the Treatment of Diabetic Macular Edema in Long-Term Cohort Study
by: Yu-Bai Chou, et al.
Published: (2024-10-01)

Combined Treatment of Persistent Diabetic Macular Edema with Aflibercept and Triamcinolone Acetonide in Pseudophakic Eyes
by: Nenad Petrovic, et al.
Published: (2023-05-01)

Predictive effect of TCED-HFV grading and imaging biomarkers on anti-VEGF therapy in diabetic macular edema
by: Lu Yu, et al.
Published: (2023-05-01)

The EQ-5D-5L valuation study for Trinidad and Tobago
by: Henry Bailey, et al.
Published: (2024-07-01)

Current approaches to the management of diabetic retinopathy
by: Tatiana Yul'evna Demidova, et al.
Published: (2014-10-01)

Evaluation of Anti-VEGF and Pan-Retinal Photocoagulation Laser Therapies in Proliferative Diabetic Retinopathy Patients: A Systematic Review
by: Senyum Indrakila, et al.
Published: (2023-08-01)

Association between quality of life and visual characteristics in individuals with diabetic retinopathy
by: Rikta Paul, et al.
Published: (2025-03-01)

Transitioning between the EQ-5D youth and adult descriptive systems in a group of adolescents
by: Janine Verstraete, et al.
Published: (2024-08-01)

Health-related quality of life of Kuwaiti adults living with diabetes
by: Maryam S. Alowayesh, et al.
Published: (2023-03-01)

Health status based on EQ-5D-5L for the cancer patient population in Malaysia
by: Sharifa Ezat Wan Puteh, et al.
Published: (2024-04-01)

Health-related quality of life and its associated factors among hemophilia patients: experience from Ethiopian Hemophilia Treatment Centre
by: Sitina Iyar, et al.
Published: (2024-01-01)

Functional results one-year following the anti-VEGF therapy in macular pathology
by: Nicoleta Anton, et al.
Published: (2023-12-01)

The Dilemma between the Randomized Control Trials and Real Life Practice in the Treatment of Retinal Diseases with Intravitreal anti-VEGF agents
by: Abdullah Özkaya, et al.
Published: (2017-05-01)

Predictive factors for treatment outcomes with intravitreal anti-vascular endothelial growth factor injections in diabetic macular edema in clinical practice
by: Rajya L Gurung, et al.
Published: (2023-04-01)