Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects
Since the novel coronavirus disease 2019 (COVID-19) outbreak, there has been an unprecedented increase in the acquisition of chest computed tomography (CT) scans. Nearly 616 million people have been infected by COVID-19 worldwide to date, of whom many were subjected to CT scanning. CT exposes the pa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/3043 |
| _version_ | 1827641097653846016 |
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| author | Mandeep Garg Vahid Karami Javad Moazen Thomas Kwee Ashu Seith Bhalla Daryoush Shahbazi-Gahrouei Yu-Hsuan Joni Shao |
| author_facet | Mandeep Garg Vahid Karami Javad Moazen Thomas Kwee Ashu Seith Bhalla Daryoush Shahbazi-Gahrouei Yu-Hsuan Joni Shao |
| author_sort | Mandeep Garg |
| collection | DOAJ |
| description | Since the novel coronavirus disease 2019 (COVID-19) outbreak, there has been an unprecedented increase in the acquisition of chest computed tomography (CT) scans. Nearly 616 million people have been infected by COVID-19 worldwide to date, of whom many were subjected to CT scanning. CT exposes the patients to hazardous ionizing radiation, which can damage the genetic material in the cells, leading to stochastic health effects in the form of heritable genetic mutations and increased cancer risk. These probabilistic, long-term carcinogenic effects of radiation can be seen over a lifetime and may sometimes take several decades to manifest. This review briefly describes what is known about the health effects of radiation, the lowest dose for which there exists compelling evidence about increased radiation-induced cancer risk and the evidence regarding this risk at typical CT doses. The lifetime attributable risk (LAR) of cancer from low- and standard-dose chest CT scans performed in COVID-19 subjects is also discussed along with the projected number of future cancers that could be related to chest CT scans performed during the COVID-19 pandemic. The LAR of cancer Incidence from chest CT has also been compared with those from other radiation sources, daily life risks and lifetime baseline risk. |
| first_indexed | 2024-03-09T17:08:32Z |
| format | Article |
| id | doaj.art-9e364cae476946298faeeb9277d98fe1 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:32Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9e364cae476946298faeeb9277d98fe12023-11-24T14:17:40ZengMDPI AGDiagnostics2075-44182022-12-011212304310.3390/diagnostics12123043Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia SubjectsMandeep Garg0Vahid Karami1Javad Moazen2Thomas Kwee3Ashu Seith Bhalla4Daryoush Shahbazi-Gahrouei5Yu-Hsuan Joni Shao6Department of Radiodiagnosis & Imaging, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, IndiaClinical Research Development Unite, Ganjavian Hospital, Dezful University of Medical Sciences, Dezful 6461653476, IranInfectious and Tropical Diseases Research Center, School of Medicine, Dezful University of Medical Sciences, Dezful 6461653480, IranDepartment of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Hanzeplein, 9700 Groningen, The NetherlandsDepartment of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Medical Physics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan 8174673461, IranGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 106, TaiwanSince the novel coronavirus disease 2019 (COVID-19) outbreak, there has been an unprecedented increase in the acquisition of chest computed tomography (CT) scans. Nearly 616 million people have been infected by COVID-19 worldwide to date, of whom many were subjected to CT scanning. CT exposes the patients to hazardous ionizing radiation, which can damage the genetic material in the cells, leading to stochastic health effects in the form of heritable genetic mutations and increased cancer risk. These probabilistic, long-term carcinogenic effects of radiation can be seen over a lifetime and may sometimes take several decades to manifest. This review briefly describes what is known about the health effects of radiation, the lowest dose for which there exists compelling evidence about increased radiation-induced cancer risk and the evidence regarding this risk at typical CT doses. The lifetime attributable risk (LAR) of cancer from low- and standard-dose chest CT scans performed in COVID-19 subjects is also discussed along with the projected number of future cancers that could be related to chest CT scans performed during the COVID-19 pandemic. The LAR of cancer Incidence from chest CT has also been compared with those from other radiation sources, daily life risks and lifetime baseline risk.https://www.mdpi.com/2075-4418/12/12/3043computed tomographychestradiation riskCOVID-19cancer |
| spellingShingle | Mandeep Garg Vahid Karami Javad Moazen Thomas Kwee Ashu Seith Bhalla Daryoush Shahbazi-Gahrouei Yu-Hsuan Joni Shao Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects Diagnostics computed tomography chest radiation risk COVID-19 cancer |
| title | Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects |
| title_full | Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects |
| title_fullStr | Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects |
| title_full_unstemmed | Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects |
| title_short | Radiation Exposure and Lifetime Attributable Risk of Cancer Incidence and Mortality from Low- and Standard-Dose CT Chest: Implications for COVID-19 Pneumonia Subjects |
| title_sort | radiation exposure and lifetime attributable risk of cancer incidence and mortality from low and standard dose ct chest implications for covid 19 pneumonia subjects |
| topic | computed tomography chest radiation risk COVID-19 cancer |
| url | https://www.mdpi.com/2075-4418/12/12/3043 |
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