Cancer-associated fibroblasts: The chief architect in the tumor microenvironment
Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major players in tumor stroma. The heterogeneous sources of origin and subsequent impacts of crosstalk with breast cancer cells fla...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1089068/full |
| _version_ | 1811175352456708096 |
|---|---|
| author | Mrinmoy Sarkar Mrinmoy Sarkar Tristan Nguyen Esheksha Gundre Olajumoke Ogunlusi Mohanad El-Sobky Biplab Giri Tapasree Roy Sarkar |
| author_facet | Mrinmoy Sarkar Mrinmoy Sarkar Tristan Nguyen Esheksha Gundre Olajumoke Ogunlusi Mohanad El-Sobky Biplab Giri Tapasree Roy Sarkar |
| author_sort | Mrinmoy Sarkar |
| collection | DOAJ |
| description | Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major players in tumor stroma. The heterogeneous sources of origin and subsequent impacts of crosstalk with breast cancer cells flaunt serious challenges before current therapies to cure triple-negative breast cancer (TNBC) and other cancers. The positive and reciprocal feedback of CAFs to induce cancer cells dictates their mutual synergy in establishing malignancy. Their substantial role in creating a tumor-promoting niche has reduced the efficacy of several anti-cancer treatments, including radiation, chemotherapy, immunotherapy, and endocrine therapy. Over the years, there has been an emphasis on understanding CAF-induced therapeutic resistance in order to enhance cancer therapy results. CAFs, in the majority of cases, employ crosstalk, stromal management, and other strategies to generate resilience in surrounding tumor cells. This emphasizes the significance of developing novel strategies that target particular tumor-promoting CAF subpopulations, which will improve treatment sensitivity and impede tumor growth. In this review, we discuss the current understanding of the origin and heterogeneity of CAFs, their role in tumor progression, and altering the tumor response to therapeutic agents in breast cancer. In addition, we also discuss the potential and possible approaches for CAF-mediated therapies. |
| first_indexed | 2024-04-10T19:34:39Z |
| format | Article |
| id | doaj.art-9e367c3905ea4e52bb38da7e3e076ca2 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T19:34:39Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9e367c3905ea4e52bb38da7e3e076ca22023-01-30T08:29:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-01-011110.3389/fcell.2023.10890681089068Cancer-associated fibroblasts: The chief architect in the tumor microenvironmentMrinmoy Sarkar0Mrinmoy Sarkar1Tristan Nguyen2Esheksha Gundre3Olajumoke Ogunlusi4Mohanad El-Sobky5Biplab Giri6Tapasree Roy Sarkar7Department of Biology, Texas A&M University, College Station, TX, United StatesCancer Biology and Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, IndiaDepartment of Biology, Texas A&M University, College Station, TX, United StatesDepartment of Biology, Texas A&M University, College Station, TX, United StatesDepartment of Biology, Texas A&M University, College Station, TX, United StatesDepartment of Biology, Texas A&M University, College Station, TX, United StatesDepartment of Physiology, University of Gour Banga, English Bazar, IndiaDepartment of Biology, Texas A&M University, College Station, TX, United StatesStromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major players in tumor stroma. The heterogeneous sources of origin and subsequent impacts of crosstalk with breast cancer cells flaunt serious challenges before current therapies to cure triple-negative breast cancer (TNBC) and other cancers. The positive and reciprocal feedback of CAFs to induce cancer cells dictates their mutual synergy in establishing malignancy. Their substantial role in creating a tumor-promoting niche has reduced the efficacy of several anti-cancer treatments, including radiation, chemotherapy, immunotherapy, and endocrine therapy. Over the years, there has been an emphasis on understanding CAF-induced therapeutic resistance in order to enhance cancer therapy results. CAFs, in the majority of cases, employ crosstalk, stromal management, and other strategies to generate resilience in surrounding tumor cells. This emphasizes the significance of developing novel strategies that target particular tumor-promoting CAF subpopulations, which will improve treatment sensitivity and impede tumor growth. In this review, we discuss the current understanding of the origin and heterogeneity of CAFs, their role in tumor progression, and altering the tumor response to therapeutic agents in breast cancer. In addition, we also discuss the potential and possible approaches for CAF-mediated therapies.https://www.frontiersin.org/articles/10.3389/fcell.2023.1089068/fullCAFbreast cancertumor microenvironmentheterogeneitytargeting |
| spellingShingle | Mrinmoy Sarkar Mrinmoy Sarkar Tristan Nguyen Esheksha Gundre Olajumoke Ogunlusi Mohanad El-Sobky Biplab Giri Tapasree Roy Sarkar Cancer-associated fibroblasts: The chief architect in the tumor microenvironment Frontiers in Cell and Developmental Biology CAF breast cancer tumor microenvironment heterogeneity targeting |
| title | Cancer-associated fibroblasts: The chief architect in the tumor microenvironment |
| title_full | Cancer-associated fibroblasts: The chief architect in the tumor microenvironment |
| title_fullStr | Cancer-associated fibroblasts: The chief architect in the tumor microenvironment |
| title_full_unstemmed | Cancer-associated fibroblasts: The chief architect in the tumor microenvironment |
| title_short | Cancer-associated fibroblasts: The chief architect in the tumor microenvironment |
| title_sort | cancer associated fibroblasts the chief architect in the tumor microenvironment |
| topic | CAF breast cancer tumor microenvironment heterogeneity targeting |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1089068/full |
| work_keys_str_mv | AT mrinmoysarkar cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT mrinmoysarkar cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT tristannguyen cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT eshekshagundre cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT olajumokeogunlusi cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT mohanadelsobky cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT biplabgiri cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment AT tapasreeroysarkar cancerassociatedfibroblaststhechiefarchitectinthetumormicroenvironment |