Cancer-associated fibroblasts: The chief architect in the tumor microenvironment

Cancer-associated fibroblasts: The chief architect in the tumor microenvironment

Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major players in tumor stroma. The heterogeneous sources of origin and subsequent impacts of crosstalk with breast cancer cells fla...

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Bibliographic Details
Main Authors: Mrinmoy Sarkar, Tristan Nguyen, Esheksha Gundre, Olajumoke Ogunlusi, Mohanad El-Sobky, Biplab Giri, Tapasree Roy Sarkar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CAF
breast cancer
tumor microenvironment
heterogeneity
targeting
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1089068/full

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