NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

Skeletal muscle from mdx mice is characterized by increased Nox2 ROS, altered microtubule network, increased muscle stiffness, and decreased muscle/respiratory function. While microtubule de-tyrosination has been suggested to increase stiffness and Nox2 ROS production in isolated single myofibers, i...

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Bibliographic Details
Main Authors: James Anthony Loehr, Shang Wang, Tanya R Cully, Rituraj Pal, Irina V Larina, Kirill V Larin, George G Rodney
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
optical coherence elastography
microtubule
fibrosis
NADPH Oxidase
reactive oxygen species
muscular dystrophy
Online Access:https://elifesciences.org/articles/31732

Internet

https://elifesciences.org/articles/31732

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