The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis
Ovarian cancer cells mainly metastasise within the peritoneal cavity, the lethal consequence of tumour progression in this cancer type. Classically, changes in tumour cells, such as epithelial to mesenchymal transition, involve the down-regulatinon of E-cadherin, activation of extracellular protease...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
|
| Series: | EJC Supplements |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1359634919300023 |
| _version_ | 1818478475640569856 |
|---|---|
| author | Marta Hergueta-Redondo Héctor Peinado |
| author_facet | Marta Hergueta-Redondo Héctor Peinado |
| author_sort | Marta Hergueta-Redondo |
| collection | DOAJ |
| description | Ovarian cancer cells mainly metastasise within the peritoneal cavity, the lethal consequence of tumour progression in this cancer type. Classically, changes in tumour cells, such as epithelial to mesenchymal transition, involve the down-regulatinon of E-cadherin, activation of extracellular proteases and integrin-mediated adhesion. However, our current understanding of ovarian tumour progression suggests the implication of both intrinsic and extrinsic factors. It has been proposed that ovarian cancer metastases are a consequence of the crosstalk between cancer cells and the tumour microenvironment by soluble factors and extracellular vesicles. Characterisation of the alterations in both the tumour cells and the surrounding microenvironment has emerged as a new research field to understand ovarian cancer metastasis. In this mini review, we will summarise the most recent findings, focusing our attention on the role of secreted factors and extracellular vesicles in ovarian cancer metastasis. |
| first_indexed | 2024-12-10T09:48:48Z |
| format | Article |
| id | doaj.art-9e37508e7d1f45969ca582ce17dbec04 |
| institution | Directory Open Access Journal |
| issn | 1359-6349 |
| language | English |
| last_indexed | 2024-12-10T09:48:48Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EJC Supplements |
| spelling | doaj.art-9e37508e7d1f45969ca582ce17dbec042022-12-22T01:53:43ZengElsevierEJC Supplements1359-63492020-08-01153848The influence of secreted factors and extracellular vesicles in ovarian cancer metastasisMarta Hergueta-Redondo0Héctor Peinado1Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, SpainCorresponding author:; Microenvironment and Metastasis Group, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, SpainOvarian cancer cells mainly metastasise within the peritoneal cavity, the lethal consequence of tumour progression in this cancer type. Classically, changes in tumour cells, such as epithelial to mesenchymal transition, involve the down-regulatinon of E-cadherin, activation of extracellular proteases and integrin-mediated adhesion. However, our current understanding of ovarian tumour progression suggests the implication of both intrinsic and extrinsic factors. It has been proposed that ovarian cancer metastases are a consequence of the crosstalk between cancer cells and the tumour microenvironment by soluble factors and extracellular vesicles. Characterisation of the alterations in both the tumour cells and the surrounding microenvironment has emerged as a new research field to understand ovarian cancer metastasis. In this mini review, we will summarise the most recent findings, focusing our attention on the role of secreted factors and extracellular vesicles in ovarian cancer metastasis.http://www.sciencedirect.com/science/article/pii/S1359634919300023CancerExosomesExtracellular vesiclesMetastasis |
| spellingShingle | Marta Hergueta-Redondo Héctor Peinado The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis EJC Supplements Cancer Exosomes Extracellular vesicles Metastasis |
| title | The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis |
| title_full | The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis |
| title_fullStr | The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis |
| title_full_unstemmed | The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis |
| title_short | The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis |
| title_sort | influence of secreted factors and extracellular vesicles in ovarian cancer metastasis |
| topic | Cancer Exosomes Extracellular vesicles Metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S1359634919300023 |
| work_keys_str_mv | AT martaherguetaredondo theinfluenceofsecretedfactorsandextracellularvesiclesinovariancancermetastasis AT hectorpeinado theinfluenceofsecretedfactorsandextracellularvesiclesinovariancancermetastasis AT martaherguetaredondo influenceofsecretedfactorsandextracellularvesiclesinovariancancermetastasis AT hectorpeinado influenceofsecretedfactorsandextracellularvesiclesinovariancancermetastasis |