Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against <i>Trypanosoma cruzi</i>: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against <i>Trypanosoma cruzi</i>: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Chagas disease, a century-old disease that mainly affects the impoverished population in Latin America, causes high morbidity and mortality in endemic countries. The available drugs, benznidazole (Bz) and nifurtimox, have limited effectiveness and intense side effects. Drug repurposing, and the deve...

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Bibliographic Details
Main Authors: Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araújo Souto, Maurício Silva dos Santos, Mirian Claudia de Souza Pereira
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
<i>Trypanosoma cruzi</i>
pyrazole
thiazoline
chemotherapy
Chagas disease
Online Access:https://www.mdpi.com/1999-4923/14/5/995

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