Current status and future promise of next-generation poly (ADP-Ribose) polymerase 1-selective inhibitor AZD5305

Current status and future promise of next-generation poly (ADP-Ribose) polymerase 1-selective inhibitor AZD5305

The family of poly (ADP-ribose) polymerases (PARPs) consists of 17 members, which have been demonstrated as having effects on a series of cellular processes, including DNA replication and repair. PARP inhibitors (PARPi) suppress DNA repair through “PARP trapping”, thus, constitute an important treat...

Full description

Bibliographic Details
Main Authors: Jingcao Zheng, Zhengyu Li, Wenjiao Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
PARP inhibitors
improved selectivity
novel therapy
oncology
AZD5305
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.979873/full

Similar Items

Similar Items