Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Glioblastoma is one of the most common and aggressive forms of brain tumor, a rare disease for which there is a great need for innovative therapies. ONC201, a new drug substance, has been used in a compassionate treatment program where the choice of dosage form and regimen have yet to be justified....

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Bibliographic Details
Main Authors: Maxime Annereau, Marina Vignes, Lucas Denis, André Rieutord, François-Xavier Legrand, François Rioblanc, Muriel Paul, Jacques Grill, Philippe-Henri Secretan, Bernard Do
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceutics
Subjects:
ONC201
oxidation mechanism
photolysis mechanism
DFT
antioxidant effects
preformulation studies
Online Access:https://www.mdpi.com/1999-4923/15/10/2371

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