A new gene-scoring method for uncovering novel glaucoma-related genes using non-negative matrix factorization based on RNA-seq data

A new gene-scoring method for uncovering novel glaucoma-related genes using non-negative matrix factorization based on RNA-seq data

Early diagnosis and treatment of glaucoma are challenging. The discovery of glaucoma biomarkers based on gene expression data could potentially provide new insights for early diagnosis, monitoring, and treatment options of glaucoma. Non-negative Matrix Factorization (NMF) has been widely used in num...

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Bibliographic Details
Main Authors: Xiaoqin Huang, Akhilesh K. Bajpai, Jian Sun, Fuyi Xu, Lu Lu, Siamak Yousefi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Genetics
Subjects:
glaucoma
RNA-seq
DEG
NMF
BXD strains
pathway analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1204909/full

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