Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma

Exosomal lncRNA HOTAIR induce macrophages to M2 polarization via PI3K/ p-AKT /AKT pathway and promote EMT and metastasis in laryngeal squamous cell carcinoma

Abstract Exosomes are a new way of the communication between the tumor cell and macrophage in the micro-environment. The macrophage can be induced to different phenotypes according to the different tumors. In the present study, long-chain noncoding RNA HOTAIR (lncRNA HOTAIR) was highly expressed in...

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Bibliographic Details
Main Authors: Jingting Wang, Nan Wang, Zeyu Zheng, Yanlu Che, Masanobu Suzuki, Satoshi Kano, Jianguang Lu, Peng Wang, Yanan Sun, Akihiro Homma
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Cancer
Subjects:
lncRNA HOTAIR
Exosomes
Macrophage
LSCC
EMT
Online Access:https://doi.org/10.1186/s12885-022-10210-5

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