空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目
Abstract Background The effect of long‐standing prediabetes or its transition on incident cardiovascular disease (CVD) is unclear. This study aimed to evaluate the association of changes in fasting blood glucose (FBG) status with the risk of developing CVD. Methods This research included 12 145 Chin...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13350 |
| _version_ | 1797904647716864000 |
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| author | Ye Tong Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Xiangfeng Lu Chong Shen Dongfeng Gu |
| author_facet | Ye Tong Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Xiangfeng Lu Chong Shen Dongfeng Gu |
| author_sort | Ye Tong |
| collection | DOAJ |
| description | Abstract Background The effect of long‐standing prediabetes or its transition on incident cardiovascular disease (CVD) is unclear. This study aimed to evaluate the association of changes in fasting blood glucose (FBG) status with the risk of developing CVD. Methods This research included 12 145 Chinese adults aged 35–74 years and free from diabetes mellitus (DM) at baseline. Study participants were cross‐classified into six categories according to glucose at the first (1998–2001) and the second visit after 8 years: normal fasting glucose (NFG; 50–99 mg/dl), impaired FBG (IFG; 100–125 mg/dl), and DM. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for CVD associated with transition of glucose status. Results During a median follow‐up of 5.5 years, 373 incident CVD cases occurred. Compared with participants remaining persistent NFG, a higher risk of developing CVD was identified among those remaining persistent IFG, progressing to DM from NFG or from IFG, with the multivariate‐adjusted HR (95% CI) of 1.792 (1.141, 2.816), 1.723 (1.122, 2.645) and 1.946 (1.120, 3.381), respectively. Furthermore, when stratified by glucose status at baseline, persistent IFG and progression from IFG to DM still increased CVD risk in comparison with reversion from IFG to NFG, with the multivariate‐adjusted HR (95% CI) of 1.594 (1.003, 2.532) and 1.913 (1.080, 3.389). Conclusions Participants with long‐standing IFG and progressing to DM had a higher risk of developing CVD. Further well‐designed studies are warranted to assess the association of other phenotypes or prediabetes duration with CVD. |
| first_indexed | 2024-04-10T09:52:17Z |
| format | Article |
| id | doaj.art-9e3d12d64d3e4f8687267eb45b674cd7 |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-10T09:52:17Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-9e3d12d64d3e4f8687267eb45b674cd72023-02-16T23:09:18ZengWileyJournal of Diabetes1753-03931753-04072023-02-0115211012010.1111/1753-0407.13350空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目Ye Tong0Fangchao Liu1Keyong Huang2Jianxin Li3Xueli Yang4Jichun Chen5Xiaoqing Liu6Jie Cao7Shufeng Chen8Ling Yu9Yingxin Zhao10Xianping Wu11Liancheng Zhao12Ying Li13Dongsheng Hu14Jianfeng Huang15Xiangfeng Lu16Chong Shen17Dongfeng Gu18Department of Epidemiology, Center for Global Health School of Public Health, Nanjing Medical University Nanjing ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaTianjin Key Laboratory of Environment, Nutrition and Public Health, Department of Occupational and Environmental Health School of Public Health, Tianjin Medical University Tianjin ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDivision of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular Institute Guangzhou ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Cardiology Fujian Provincial Hospital Fuzhou ChinaCardio‐Cerebrovascular Control and Research Center Institute of Basic Medicine, Shandong Academy of Medical Sciences Jinan ChinaSichuan Center for Disease Control and Prevention Chengdu ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Epidemiology and Health Statistics College of Public Health, Zhengzhou University Zhengzhou ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaKey Laboratory of Cardiovascular Epidemiology & Department of Epidemiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Epidemiology, Center for Global Health School of Public Health, Nanjing Medical University Nanjing ChinaDepartment of Epidemiology, Center for Global Health School of Public Health, Nanjing Medical University Nanjing ChinaAbstract Background The effect of long‐standing prediabetes or its transition on incident cardiovascular disease (CVD) is unclear. This study aimed to evaluate the association of changes in fasting blood glucose (FBG) status with the risk of developing CVD. Methods This research included 12 145 Chinese adults aged 35–74 years and free from diabetes mellitus (DM) at baseline. Study participants were cross‐classified into six categories according to glucose at the first (1998–2001) and the second visit after 8 years: normal fasting glucose (NFG; 50–99 mg/dl), impaired FBG (IFG; 100–125 mg/dl), and DM. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for CVD associated with transition of glucose status. Results During a median follow‐up of 5.5 years, 373 incident CVD cases occurred. Compared with participants remaining persistent NFG, a higher risk of developing CVD was identified among those remaining persistent IFG, progressing to DM from NFG or from IFG, with the multivariate‐adjusted HR (95% CI) of 1.792 (1.141, 2.816), 1.723 (1.122, 2.645) and 1.946 (1.120, 3.381), respectively. Furthermore, when stratified by glucose status at baseline, persistent IFG and progression from IFG to DM still increased CVD risk in comparison with reversion from IFG to NFG, with the multivariate‐adjusted HR (95% CI) of 1.594 (1.003, 2.532) and 1.913 (1.080, 3.389). Conclusions Participants with long‐standing IFG and progressing to DM had a higher risk of developing CVD. Further well‐designed studies are warranted to assess the association of other phenotypes or prediabetes duration with CVD.https://doi.org/10.1111/1753-0407.13350心血管疾病中国人群空腹血糖受损前瞻性队列研究 |
| spellingShingle | Ye Tong Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Xiangfeng Lu Chong Shen Dongfeng Gu 空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目 Journal of Diabetes 心血管疾病 中国人群 空腹血糖受损 前瞻性队列研究 |
| title | 空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目 |
| title_full | 空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目 |
| title_fullStr | 空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目 |
| title_full_unstemmed | 空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目 |
| title_short | 空腹血糖状态变化与心血管疾病发病率:中国动脉粥样硬化性心血管疾病预测项目 |
| title_sort | 空腹血糖状态变化与心血管疾病发病率 中国动脉粥样硬化性心血管疾病预测项目 |
| topic | 心血管疾病 中国人群 空腹血糖受损 前瞻性队列研究 |
| url | https://doi.org/10.1111/1753-0407.13350 |
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