Microfluidic devices for neutrophil chemotaxis studies
Abstract Neutrophil chemotaxis plays a vital role in human immune system. Compared with traditional cell migration assays, the emergence of microfluidics provides a new research platform of cell chemotaxis study due to the advantages of visualization, precise control of chemical gradient, and small...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12967-020-02335-7 |
| _version_ | 1828886241298350080 |
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| author | Wenjie Zhao Haiping Zhao Mingxiao Li Chengjun Huang |
| author_facet | Wenjie Zhao Haiping Zhao Mingxiao Li Chengjun Huang |
| author_sort | Wenjie Zhao |
| collection | DOAJ |
| description | Abstract Neutrophil chemotaxis plays a vital role in human immune system. Compared with traditional cell migration assays, the emergence of microfluidics provides a new research platform of cell chemotaxis study due to the advantages of visualization, precise control of chemical gradient, and small consumption of reagents. A series of microfluidic devices have been fabricated to study the behavior of neutrophils exposed on controlled, stable, and complex profiles of chemical concentration gradients. In addition, microfluidic technology offers a promising way to integrate the other functions, such as cell culture, separation and analysis into a single chip. Therefore, an overview of recent developments in microfluidic-based neutrophil chemotaxis studies is presented. Meanwhile, the strength and drawbacks of these devices are compared. |
| first_indexed | 2024-12-13T11:41:17Z |
| format | Article |
| id | doaj.art-9e411b6590f7444f8c91fdc2b0f5ea0f |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-13T11:41:17Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-9e411b6590f7444f8c91fdc2b0f5ea0f2022-12-21T23:47:38ZengBMCJournal of Translational Medicine1479-58762020-04-0118111910.1186/s12967-020-02335-7Microfluidic devices for neutrophil chemotaxis studiesWenjie Zhao0Haiping Zhao1Mingxiao Li2Chengjun Huang3Institute of Microelectronics, Chinese Academy of SciencesCerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical UniversityInstitute of Microelectronics, Chinese Academy of SciencesInstitute of Microelectronics, Chinese Academy of SciencesAbstract Neutrophil chemotaxis plays a vital role in human immune system. Compared with traditional cell migration assays, the emergence of microfluidics provides a new research platform of cell chemotaxis study due to the advantages of visualization, precise control of chemical gradient, and small consumption of reagents. A series of microfluidic devices have been fabricated to study the behavior of neutrophils exposed on controlled, stable, and complex profiles of chemical concentration gradients. In addition, microfluidic technology offers a promising way to integrate the other functions, such as cell culture, separation and analysis into a single chip. Therefore, an overview of recent developments in microfluidic-based neutrophil chemotaxis studies is presented. Meanwhile, the strength and drawbacks of these devices are compared.http://link.springer.com/article/10.1186/s12967-020-02335-7MicrofluidicNeutrophil chemotaxisChemical gradientLab on a chip |
| spellingShingle | Wenjie Zhao Haiping Zhao Mingxiao Li Chengjun Huang Microfluidic devices for neutrophil chemotaxis studies Journal of Translational Medicine Microfluidic Neutrophil chemotaxis Chemical gradient Lab on a chip |
| title | Microfluidic devices for neutrophil chemotaxis studies |
| title_full | Microfluidic devices for neutrophil chemotaxis studies |
| title_fullStr | Microfluidic devices for neutrophil chemotaxis studies |
| title_full_unstemmed | Microfluidic devices for neutrophil chemotaxis studies |
| title_short | Microfluidic devices for neutrophil chemotaxis studies |
| title_sort | microfluidic devices for neutrophil chemotaxis studies |
| topic | Microfluidic Neutrophil chemotaxis Chemical gradient Lab on a chip |
| url | http://link.springer.com/article/10.1186/s12967-020-02335-7 |
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