Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds
Severe muscle injuries are a real clinical issue that still needs to be successfully addressed. Tissue engineering can represent a potential approach for this aim, but effective healing solutions have not been developed yet. In this regard, novel experimental protocols tailored to a biomimetic appro...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/10/10/1986 |
| _version_ | 1797551568697950208 |
|---|---|
| author | Silvia Baiguera Costantino Del Gaudio Felicia Carotenuto Paolo Di Nardo Laura Teodori |
| author_facet | Silvia Baiguera Costantino Del Gaudio Felicia Carotenuto Paolo Di Nardo Laura Teodori |
| author_sort | Silvia Baiguera |
| collection | DOAJ |
| description | Severe muscle injuries are a real clinical issue that still needs to be successfully addressed. Tissue engineering can represent a potential approach for this aim, but effective healing solutions have not been developed yet. In this regard, novel experimental protocols tailored to a biomimetic approach can thus be defined by properly systematizing the findings acquired so far in the biomaterials and scaffold manufacturing fields. In order to plan a more comprehensive strategy, the extracellular matrix (ECM), with its properties stimulating neomyogenesis and vascularization, should be considered as a valuable biomaterial to be used to fabricate the tissue-specific three-dimensional structure of interest. The skeletal muscle decellularized ECM can be processed and printed, e.g., by means of stereolithography, to prepare bioactive and biomimetic 3D scaffolds, including both biochemical and topographical features specifically oriented to skeletal muscle regenerative applications. This paper aims to focus on the skeletal muscle tissue engineering sector, suggesting a possible approach to develop instructive scaffolds for a guided healing process. |
| first_indexed | 2024-03-10T15:48:01Z |
| format | Article |
| id | doaj.art-9e43954d90c046919dab2e7a2b9591cd |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T15:48:01Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-9e43954d90c046919dab2e7a2b9591cd2023-11-20T16:19:43ZengMDPI AGNanomaterials2079-49912020-10-011010198610.3390/nano10101986Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic ScaffoldsSilvia Baiguera0Costantino Del Gaudio1Felicia Carotenuto2Paolo Di Nardo3Laura Teodori4Departmet of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, 00196 Roma, ItalyE. Amaldi Foundation, Via del Politecnico snc, 00133 Rome, ItalyDepartmet of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, 00196 Roma, ItalyDepartment of Clinical Science and Translational Medicine, University of Rome “Tor Vergata”, 00133 Roma, ItalyDepartmet of Fusion and Technologies for Nuclear Safety and Security, Diagnostic and Metrology (FSN-TECFIS-DIM), ENEA, 00196 Roma, ItalySevere muscle injuries are a real clinical issue that still needs to be successfully addressed. Tissue engineering can represent a potential approach for this aim, but effective healing solutions have not been developed yet. In this regard, novel experimental protocols tailored to a biomimetic approach can thus be defined by properly systematizing the findings acquired so far in the biomaterials and scaffold manufacturing fields. In order to plan a more comprehensive strategy, the extracellular matrix (ECM), with its properties stimulating neomyogenesis and vascularization, should be considered as a valuable biomaterial to be used to fabricate the tissue-specific three-dimensional structure of interest. The skeletal muscle decellularized ECM can be processed and printed, e.g., by means of stereolithography, to prepare bioactive and biomimetic 3D scaffolds, including both biochemical and topographical features specifically oriented to skeletal muscle regenerative applications. This paper aims to focus on the skeletal muscle tissue engineering sector, suggesting a possible approach to develop instructive scaffolds for a guided healing process.https://www.mdpi.com/2079-4991/10/10/1986decellularized extracellular matrixengineered muscular constructstereolithographyvolumetric muscle loss |
| spellingShingle | Silvia Baiguera Costantino Del Gaudio Felicia Carotenuto Paolo Di Nardo Laura Teodori Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds Nanomaterials decellularized extracellular matrix engineered muscular construct stereolithography volumetric muscle loss |
| title | Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds |
| title_full | Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds |
| title_fullStr | Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds |
| title_full_unstemmed | Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds |
| title_short | Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds |
| title_sort | information driven design as a potential approach for 3d printing of skeletal muscle biomimetic scaffolds |
| topic | decellularized extracellular matrix engineered muscular construct stereolithography volumetric muscle loss |
| url | https://www.mdpi.com/2079-4991/10/10/1986 |
| work_keys_str_mv | AT silviabaiguera informationdrivendesignasapotentialapproachfor3dprintingofskeletalmusclebiomimeticscaffolds AT costantinodelgaudio informationdrivendesignasapotentialapproachfor3dprintingofskeletalmusclebiomimeticscaffolds AT feliciacarotenuto informationdrivendesignasapotentialapproachfor3dprintingofskeletalmusclebiomimeticscaffolds AT paolodinardo informationdrivendesignasapotentialapproachfor3dprintingofskeletalmusclebiomimeticscaffolds AT laurateodori informationdrivendesignasapotentialapproachfor3dprintingofskeletalmusclebiomimeticscaffolds |