Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection
Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic complications in children, although there are very...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SMC MEDIA SRL
2019-09-01
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| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/1171 |
| _version_ | 1818428904031911936 |
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| author | Rashid Khan Yasmeen Ajaz Anoop Kumar Pandey Khalid AlSaffar Sunil Roy Thottuvelil Narayanan |
| author_facet | Rashid Khan Yasmeen Ajaz Anoop Kumar Pandey Khalid AlSaffar Sunil Roy Thottuvelil Narayanan |
| author_sort | Rashid Khan |
| collection | DOAJ |
| description | Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic complications in children, although there are very few such reports in adults. Postulated causal factors include vasculitis, direct endothelial damage, or acquired protein S deficiency secondary to molecular mimicry. These induced autoantibodies to protein S could lead to acquired protein S deficiency and produce a hypercoagulable state causing venous sinus thrombosis. Here we report the case of a 26-year-old man who presented with cortical venous sinus thrombosis and acute pulmonary embolism following varicella infection. Both conditions responded to anticoagulation treatment. |
| first_indexed | 2024-12-14T15:09:01Z |
| format | Article |
| id | doaj.art-9e440c0f6d1a4088958b01907cb82126 |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-12-14T15:09:01Z |
| publishDate | 2019-09-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-9e440c0f6d1a4088958b01907cb821262022-12-21T22:56:37ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942019-09-0110.12890/2019_0011711171Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella InfectionRashid Khan0Yasmeen Ajaz1Anoop Kumar Pandey2Khalid AlSaffar3Sunil Roy Thottuvelil Narayanan4Department of Internal Medicine, Belhoul Speciality Hospital, Dubai, UAEDepartment of Internal Medicine, Belhoul Speciality Hospital, Dubai, UAEDepartment of Radiology, Belhoul Speciality Hospital, Dubai, UAEDepartment of Neurology, Belhoul Speciality Hospital, Dubai, UAEDepartment of Cardiology, Belhoul Speciality Hospital, Dubai, UAEVaricella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic complications in children, although there are very few such reports in adults. Postulated causal factors include vasculitis, direct endothelial damage, or acquired protein S deficiency secondary to molecular mimicry. These induced autoantibodies to protein S could lead to acquired protein S deficiency and produce a hypercoagulable state causing venous sinus thrombosis. Here we report the case of a 26-year-old man who presented with cortical venous sinus thrombosis and acute pulmonary embolism following varicella infection. Both conditions responded to anticoagulation treatment.https://www.ejcrim.com/index.php/EJCRIM/article/view/1171venous thrombosispulmonary embolismvaricella infectionprotein s deficiencyhypercoagulable state |
| spellingShingle | Rashid Khan Yasmeen Ajaz Anoop Kumar Pandey Khalid AlSaffar Sunil Roy Thottuvelil Narayanan Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection European Journal of Case Reports in Internal Medicine venous thrombosis pulmonary embolism varicella infection protein s deficiency hypercoagulable state |
| title | Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection |
| title_full | Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection |
| title_fullStr | Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection |
| title_full_unstemmed | Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection |
| title_short | Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection |
| title_sort | cerebral venous thrombosis and acute pulmonary embolism following varicella infection |
| topic | venous thrombosis pulmonary embolism varicella infection protein s deficiency hypercoagulable state |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/1171 |
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