The protein quality control machinery regulates its misassembled proteasome subunits.

The protein quality control machinery regulates its misassembled proteasome subunits.

Cellular toxicity introduced by protein misfolding threatens cell fitness and viability. Failure to eliminate these polypeptides is associated with various aggregation diseases. In eukaryotes, the ubiquitin proteasome system (UPS) plays a vital role in protein quality control (PQC), by selectively t...

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Bibliographic Details
Main Authors:	Lee Zeev Peters, Ofri Karmon, Galit David-Kadoch, Rotem Hazan, Tzenlin Yu, Michael H Glickman, Shay Ben-Aroya
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-04-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC4412499?pdf=render

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