Identification of Key Genes and Pathways in RBCK1 Deficient patients by Gene Expression Profiling

Identification of Key Genes and Pathways in RBCK1 Deficient patients by Gene Expression Profiling

HOIL-1/RBCK1 deficiency is a new autosomal receive disorder with unstable cellular responses to pro-inflammatory cytokines, resulting in auto-inflammation, pyogenic bacterial disease, as well as the development of muscular amylopectinosis. This study explored the molecular mechanisms of RBCK1 defici...

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Bibliographic Details
Main Authors: Khyber Shinwari, Mikhail A. Bolkov, Irina A. Tuzankina, Valery A. Chereshnev
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2021-07-01
Series:Acta Medica Iranica
Subjects:
Primary immunodeficiency
RBCK1 deficiency
Differential expressed genes
Key pathways
Hub genes
Microarray
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/8589

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