Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts throughout the kidneys. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13327 |
| _version_ | 1797503887138095104 |
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| author | Sarah A. Bowden Euan J. Rodger Aniruddha Chatterjee Michael R. Eccles Cherie Stayner |
| author_facet | Sarah A. Bowden Euan J. Rodger Aniruddha Chatterjee Michael R. Eccles Cherie Stayner |
| author_sort | Sarah A. Bowden |
| collection | DOAJ |
| description | Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts throughout the kidneys. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD, the underlying mechanism(s) causing cystogenesis and progression of the disease are not well understood. Limited therapeutic options are currently available to slow the rate of cystic growth. Epigenetic modifications, including DNA methylation, are known to be altered in neoplasia, and several FDA-approved therapeutics target these disease-specific changes. As there are many similarities between ADPKD and neoplasia, we (and others) have postulated that ADPKD kidneys contain alterations to their epigenetic landscape that could be exploited for future therapeutic discovery. Here we summarise the current understanding of epigenetic changes that are associated with ADPKD, with a particular focus on the burgeoning field of ADPKD-specific alterations in DNA methylation. |
| first_indexed | 2024-03-10T03:56:47Z |
| format | Article |
| id | doaj.art-9e4673180fa2425cbce0a4636781f83e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:47Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9e4673180fa2425cbce0a4636781f83e2023-11-23T08:44:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241332710.3390/ijms222413327Recent Discoveries in Epigenetic Modifications of Polycystic Kidney DiseaseSarah A. Bowden0Euan J. Rodger1Aniruddha Chatterjee2Michael R. Eccles3Cherie Stayner4Department of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New ZealandDepartment of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New ZealandDepartment of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New ZealandDepartment of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New ZealandDepartment of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New ZealandAutosomal Dominant Polycystic Kidney Disease (ADPKD) is a heritable renal disease that results in end-stage kidney disease, due to the uncontrolled bilateral growth of cysts throughout the kidneys. While it is known that a mutation within a PKD-causing gene is required for the development of ADPKD, the underlying mechanism(s) causing cystogenesis and progression of the disease are not well understood. Limited therapeutic options are currently available to slow the rate of cystic growth. Epigenetic modifications, including DNA methylation, are known to be altered in neoplasia, and several FDA-approved therapeutics target these disease-specific changes. As there are many similarities between ADPKD and neoplasia, we (and others) have postulated that ADPKD kidneys contain alterations to their epigenetic landscape that could be exploited for future therapeutic discovery. Here we summarise the current understanding of epigenetic changes that are associated with ADPKD, with a particular focus on the burgeoning field of ADPKD-specific alterations in DNA methylation.https://www.mdpi.com/1422-0067/22/24/13327epigeneticsepigenomepolycystic kidney diseaseDNA methylationcystogenesisinherited kidney disease |
| spellingShingle | Sarah A. Bowden Euan J. Rodger Aniruddha Chatterjee Michael R. Eccles Cherie Stayner Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease International Journal of Molecular Sciences epigenetics epigenome polycystic kidney disease DNA methylation cystogenesis inherited kidney disease |
| title | Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease |
| title_full | Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease |
| title_fullStr | Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease |
| title_full_unstemmed | Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease |
| title_short | Recent Discoveries in Epigenetic Modifications of Polycystic Kidney Disease |
| title_sort | recent discoveries in epigenetic modifications of polycystic kidney disease |
| topic | epigenetics epigenome polycystic kidney disease DNA methylation cystogenesis inherited kidney disease |
| url | https://www.mdpi.com/1422-0067/22/24/13327 |
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