Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer’s disease assessment

Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer’s disease assessment

IntroductionPlasma Aβ42/40 ratio can help predict amyloid PET status, but its clinical utility in Alzheimer’s disease (AD) assessment is unclear.MethodsAβ42/40 ratio was measured by LC-MS/MS for 250 specimens with associated amyloid PET imaging, diagnosis, and demographic data, and for 6,192 consecu...

Full description

Bibliographic Details
Main Authors:	Darren M. Weber, Steven W. Taylor, Robert J. Lagier, Jueun C. Kim, Scott M. Goldman, Nigel J. Clarke, David E. Vaillancourt, Ranjan Duara, Karen N. McFarland, Wei-en Wang, Todd E. Golde, Michael K. Racke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Neurology
Subjects:	Alzheimer’s disease beta-amyloid blood biomarkers LC-MS/MS PET prescreening
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2024.1364658/full

Similar Items

INTEGRATED LC-MS/MS SYSTEM FOR PLANT METABOLOMICS
by: Yuji Sawada, et al.
Published: (2013-01-01)

Integrated LC-MS/MS system for plant metabolomics
by: Yuji Sawada, et al.
Published: (2013-01-01)

Determination of 355 Pesticides in Lemon and Lemon Juice by LC-MS/MS and GC-MS/MS
by: Sule Aslantas, et al.
Published: (2023-04-01)

Largazole Pharmacokinetics in Rats by LC-MS/MS
by: Mingming Yu, et al.
Published: (2014-03-01)

Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A
by: Kai Zhang
Published: (2021-08-01)

Phytoestrogens in bovine plasma and milk - LC-MS/MS analysis
by: Anna Krajčová, et al.
Published: (2010-08-01)

Determination of salicylic acid in feed using LC-MS/MS
by: Protasiuk Edyta, et al.
Published: (2018-10-01)

A Simple and Rapid LC-MS/MS Method for Therapeutic Drug Monitoring of Lenalidomide
by: Neşet Neşetoğlu, et al.
Published: (2020-06-01)

Comprehensive Characterization of 76 Pharmaceuticals and Metabolites in Wastewater by LC-MS/MS
by: Cristian Gómez-Canela, et al.
Published: (2021-09-01)

DETERMINATION OF COCAINE AND BENZOYLECGONINE IN BIOLOGICAL MATRICES BY HPLC AND LC-MS/MS.
by: Zinar Pinar GUMUS, et al.
Published: (2016-10-01)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
by: Yu-Feng Yao, et al.
Published: (2018-12-01)

Pigments’ analysis of Citrus juicing making by‐products by LC‐MS/MS and LC‐DAD
by: Eleni D. Myrtsi, et al.
Published: (2022-01-01)

Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings
by: Lisa Vermunt, et al.
Published: (2020-01-01)

Farklı Yapıdaki Organik Patlayıcı Maddelerin LC-MS-MS ile Belirlenmesi
by: Nilgün ŞEN, et al.
Published: (2015-07-01)

Determination of 77 Multiclass Pesticides and Their Metabolitesin <i>Capsicum</i> and Tomato Using GC-MS/MS and LC-MS/MS
by: Harischandra Naik Rathod, et al.
Published: (2021-03-01)

A simple and rapid LC-MS/MS method for determination of dexamethasone in bovine milk
by: Mehmet Nihat Ural, et al.
Published: (2020-03-01)

Development and validation of an LC-MS/MS method for pharmacokinetic study of lobetyolin in rats
by: Haitao Tian, et al.
Published: (2023-01-01)

Development and validation of analytical method for Naftopidil in human plasma by LC–MS/MS
by: Pritam S. Jain, et al.
Published: (2015-09-01)

Quantitative LC–MS/MS uncovers the regulatory role of autophagy in immune thrombocytopenia
by: Rui-Jie Sun, et al.
Published: (2021-10-01)

Development and validation of an LC-MS/MS method for the determination of adapalene in pharmaceutical forms for skin application
by: Dobričić Vladimir, et al.
Published: (2016-01-01)

LC-MS/MS Determination of Tropane Alkaloids in Maize Crop
by: Vuković Gorica, et al.
Published: (2018-12-01)

Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats
by: Woojin Kim, et al.
Published: (2023-03-01)

LC-MS/MS and LC-UV Determination of Moniliformin by Adding Lanthanide Ions to the Mobile Phase
by: Terenzio Bertuzzi, et al.
Published: (2019-09-01)

A Rapid LC-MS/MS-PRM Assay for Serologic Quantification of Sialylated O-HPX Glycoforms in Patients with Liver Fibrosis
by: Aswini Panigrahi, et al.
Published: (2022-03-01)

Optimization of a Simplified and Effective Analytical Method of Pesticide Residues in Mealworms (<i>Tenebrio molitor</i> Larvae) Combined with GC–MS/MS and LC–MS/MS
by: Leesun Kim, et al.
Published: (2020-07-01)

A selective detection of lysophosphatidylcholine in dried blood spots for diagnosis of adrenoleukodystrophy by LC-MS/MS
by: Ryuichi Mashima, et al.
Published: (2016-06-01)

LC–MS/MS, GC–MS and molecular docking analysis for phytochemical fingerprint and bioactivity of Beta vulgaris L.
by: Özge Üst, et al.
Published: (2024-03-01)

Determination of Ruboxistaurin analysis in rat plasma utilizing LC–MS/MS technique
by: Bushra T. AlQuadeib, et al.
Published: (2023-04-01)

LC-MS-MS identification of drug metabolites obtained by metalloporphyrin mediated oxidation
by: Maurin Andrea J. M., et al.
Published: (2003-01-01)

Determination of kanamycin residue in anatolian buffalo milk by lc-ms/ms
by: Ulas ACAROZ, et al.
Published: (2019-08-01)

Determination and pharmacokinetics study of oxyclozanide suspension in cattle by LC-MS/MS
by: Jili Zhang, et al.
Published: (2019-06-01)

Determination of 73 multi-class pesticides in okra (Abelmoschus esculentus L.) fruits using LC–MS/MS and GC–MS/MS and estimation of analytical uncertainty of measurement
by: M.S. Pallavi, et al.
Published: (2023-10-01)

Quantification of 363 Pesticides in Leafy Vegetables (Dill, Rocket and Parsley) in the Turkey Market by Using QuEChERS with LC-MS/MS and GC-MS/MS
by: Bilge Deveci, et al.
Published: (2023-02-01)

An innovative impurity profiling of Avanafil using LC and LC-MS/MS with in-silico toxicity prediction
by: Patel Mital, et al.
Published: (2020-08-01)

Bioanalytical method development and validation for quantification of amivantamab in rat plasma by LC-MS/MS
by: Pridhvi Krishna Gaddey, et al.
Published: (2024-04-01)

Dissipation of methomyl residues in tomato fruits, soil and water using LC-MS/MS
by: Dalia El-Hefny, et al.
Published: (2019-10-01)

LC-MS/MS method for the detection of multiple classes of shellfish toxins
by: Ling Jan Chiou, et al.
Published: (2019-06-01)

Simultaneous determination of candesartan and hydrochlorothiazide in human plasma by LC-MS/MS
by: Mohan Gandhi Bonthu, et al.
Published: (2018-06-01)

Proteome dataset of Hemileia vastatrix by LC–MS/MS label-free identification
by: Natália Faustino Cury, et al.
Published: (2022-08-01)

LC-MS/MS Determination of 21 Non-Steroidal Anti-Inflammatory Drugs Residues in Animal Milk and Muscles
by: Marta Pietruk, et al.
Published: (2021-09-01)