Innovative Strategies for Drug Delivery to the Ocular Posterior Segment
Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new per...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/7/1862 |
| _version_ | 1797587809460027392 |
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| author | Andrea Gabai Marco Zeppieri Lucia Finocchio Carlo Salati |
| author_facet | Andrea Gabai Marco Zeppieri Lucia Finocchio Carlo Salati |
| author_sort | Andrea Gabai |
| collection | DOAJ |
| description | Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new perspectives in this field. The aim of this mini-review is to highlight promising strategies reported in the current literature based on innovative routes to overcome the anatomical and physiological barriers of the vitreoretinal structures. The paper also describes the challenges in finding appropriate and pertinent treatments that provide safety and efficacy and the problems related to patient compliance, acceptability, effectiveness, and sustained drug delivery. The clinical application of these experimental approaches can help pave the way for standardizing the use of DDSs in developing enhanced treatment strategies and personalized therapeutic options for ocular pathologies. |
| first_indexed | 2024-03-11T00:44:07Z |
| format | Article |
| id | doaj.art-9e478032c2904bccad6b961dd2d80933 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T00:44:07Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9e478032c2904bccad6b961dd2d809332023-11-18T20:54:55ZengMDPI AGPharmaceutics1999-49232023-07-01157186210.3390/pharmaceutics15071862Innovative Strategies for Drug Delivery to the Ocular Posterior SegmentAndrea Gabai0Marco Zeppieri1Lucia Finocchio2Carlo Salati3Department of Ophthalmology, University Hospital of Udine, 33100 Udine, ItalyDepartment of Ophthalmology, University Hospital of Udine, 33100 Udine, ItalyDepartment of Ophthalmology, University Hospital of Udine, 33100 Udine, ItalyDepartment of Ophthalmology, University Hospital of Udine, 33100 Udine, ItalyInnovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new perspectives in this field. The aim of this mini-review is to highlight promising strategies reported in the current literature based on innovative routes to overcome the anatomical and physiological barriers of the vitreoretinal structures. The paper also describes the challenges in finding appropriate and pertinent treatments that provide safety and efficacy and the problems related to patient compliance, acceptability, effectiveness, and sustained drug delivery. The clinical application of these experimental approaches can help pave the way for standardizing the use of DDSs in developing enhanced treatment strategies and personalized therapeutic options for ocular pathologies.https://www.mdpi.com/1999-4923/15/7/1862drug delivery systems (DDSs)nanotechnologymatricesocular posterior segmentvitreoretinal |
| spellingShingle | Andrea Gabai Marco Zeppieri Lucia Finocchio Carlo Salati Innovative Strategies for Drug Delivery to the Ocular Posterior Segment Pharmaceutics drug delivery systems (DDSs) nanotechnology matrices ocular posterior segment vitreoretinal |
| title | Innovative Strategies for Drug Delivery to the Ocular Posterior Segment |
| title_full | Innovative Strategies for Drug Delivery to the Ocular Posterior Segment |
| title_fullStr | Innovative Strategies for Drug Delivery to the Ocular Posterior Segment |
| title_full_unstemmed | Innovative Strategies for Drug Delivery to the Ocular Posterior Segment |
| title_short | Innovative Strategies for Drug Delivery to the Ocular Posterior Segment |
| title_sort | innovative strategies for drug delivery to the ocular posterior segment |
| topic | drug delivery systems (DDSs) nanotechnology matrices ocular posterior segment vitreoretinal |
| url | https://www.mdpi.com/1999-4923/15/7/1862 |
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