A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis
Abstract Background Rhinovirus is a common viral aetiology of upper respiratory infection and is mostly associated with common cold or flu-like illness. Although rhinovirus has been recognized as a pathogen for lower respiratory infections in severe cases credited to advances in molecular detection,...
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BMC
2022-04-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-022-01799-x |
| _version_ | 1818147427240116224 |
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| author | Jun Liu Hongwei Zhao Ziheng Feng Yingchao Liu Qianyu Feng Suyun Qian Lili Xu Hengmiao Gao Zhengde Xie |
| author_facet | Jun Liu Hongwei Zhao Ziheng Feng Yingchao Liu Qianyu Feng Suyun Qian Lili Xu Hengmiao Gao Zhengde Xie |
| author_sort | Jun Liu |
| collection | DOAJ |
| description | Abstract Background Rhinovirus is a common viral aetiology of upper respiratory infection and is mostly associated with common cold or flu-like illness. Although rhinovirus has been recognized as a pathogen for lower respiratory infections in severe cases credited to advances in molecular detection, central nervous system involvement and multiorgan dysfunction are extremely rare. Case presentation A previously healthy 10-year-old girl developed fever, sore throat and conjunctive injection after contact with an upper respiratory infection patient, followed by seizures, haematuria, and severe diarrhoea. She experienced viral sepsis and multiorgan dysfunction after admission. Cerebral computed tomography showed significant diffuse encephaledema. Cerebrospinal fluid analysis showed significantly elevated protein levels. After her consciousness disturbance improved, she still took a long time to recover from haematuria and diarrhoea. We identified a rarely reported rhinovirus A45 in her oropharyngeal and anal swabs by metagenomic next-generation sequencing, and bacterial culture of blood specimens yielded negative results. Conclusions This case presents a patient with severe rhinovirus infection, which was very likely responsible for her central nervous system symptoms and viral sepsis. |
| first_indexed | 2024-12-11T12:35:04Z |
| format | Article |
| id | doaj.art-9e479f9b29364cc99633dc72900c339b |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-11T12:35:04Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-9e479f9b29364cc99633dc72900c339b2022-12-22T01:07:09ZengBMCVirology Journal1743-422X2022-04-0119111010.1186/s12985-022-01799-xA severe case of human rhinovirus A45 with central nervous system involvement and viral sepsisJun Liu0Hongwei Zhao1Ziheng Feng2Yingchao Liu3Qianyu Feng4Suyun Qian5Lili Xu6Hengmiao Gao7Zhengde Xie8Beijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthBeijing Key Laboratory of Paediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Paediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Paediatric Research Institute, Department of Paediatric Critical Care Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s HealthAbstract Background Rhinovirus is a common viral aetiology of upper respiratory infection and is mostly associated with common cold or flu-like illness. Although rhinovirus has been recognized as a pathogen for lower respiratory infections in severe cases credited to advances in molecular detection, central nervous system involvement and multiorgan dysfunction are extremely rare. Case presentation A previously healthy 10-year-old girl developed fever, sore throat and conjunctive injection after contact with an upper respiratory infection patient, followed by seizures, haematuria, and severe diarrhoea. She experienced viral sepsis and multiorgan dysfunction after admission. Cerebral computed tomography showed significant diffuse encephaledema. Cerebrospinal fluid analysis showed significantly elevated protein levels. After her consciousness disturbance improved, she still took a long time to recover from haematuria and diarrhoea. We identified a rarely reported rhinovirus A45 in her oropharyngeal and anal swabs by metagenomic next-generation sequencing, and bacterial culture of blood specimens yielded negative results. Conclusions This case presents a patient with severe rhinovirus infection, which was very likely responsible for her central nervous system symptoms and viral sepsis.https://doi.org/10.1186/s12985-022-01799-xRhinovirusCentral nervous system involvementViral sepsis |
| spellingShingle | Jun Liu Hongwei Zhao Ziheng Feng Yingchao Liu Qianyu Feng Suyun Qian Lili Xu Hengmiao Gao Zhengde Xie A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis Virology Journal Rhinovirus Central nervous system involvement Viral sepsis |
| title | A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis |
| title_full | A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis |
| title_fullStr | A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis |
| title_full_unstemmed | A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis |
| title_short | A severe case of human rhinovirus A45 with central nervous system involvement and viral sepsis |
| title_sort | severe case of human rhinovirus a45 with central nervous system involvement and viral sepsis |
| topic | Rhinovirus Central nervous system involvement Viral sepsis |
| url | https://doi.org/10.1186/s12985-022-01799-x |
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