Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT
This study evaluated dose differences in normal organs at risk, such as the lungs, heart, left anterior descending artery (LAD), right coronary artery, left ventricle, and right breast under personalized breast holder (PERSBRA), when using intensity-modulated radiation therapy (IMRT). This study eva...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/12/9/1368 |
| _version_ | 1797486172275998720 |
|---|---|
| author | Chiu-Ping Chen Tung-Ho Chen Jeng-Fong Chiou Yi-Ju Chen Chia-Chun Kuo Kuo-Hsiung Tseng Meng-Yun Chung Chun-You Chen Jeng-You Wu Long-Sheng Lu Shih-Ming Hsu |
| author_facet | Chiu-Ping Chen Tung-Ho Chen Jeng-Fong Chiou Yi-Ju Chen Chia-Chun Kuo Kuo-Hsiung Tseng Meng-Yun Chung Chun-You Chen Jeng-You Wu Long-Sheng Lu Shih-Ming Hsu |
| author_sort | Chiu-Ping Chen |
| collection | DOAJ |
| description | This study evaluated dose differences in normal organs at risk, such as the lungs, heart, left anterior descending artery (LAD), right coronary artery, left ventricle, and right breast under personalized breast holder (PERSBRA), when using intensity-modulated radiation therapy (IMRT). This study evaluated the radiation protection offered by PERSBRA in left breast cancer radiation therapy. Here, we retrospectively collected data from 24 patients with left breast cancer who underwent breast-conserving surgery as well as IMRT radiotherapy. We compared the dose differences in target coverage and organs at risk with and without PERSBRA. For target coverage, tumor prescribed dose 95% coverage, conformity index, and homogeneity index were evaluated. For organs at risk, we compared the mean heart dose, mean left ventricle dose, LAD maximum and mean dose, mean left lung receiving 20 Gy, 10 Gy, and 5 Gy of left lung volume, maximum and mean coronary artery of the right, maximum of right breast, and mean dose. Good target coverage was achieved with and without PERSBRA. When PERSBRA was used with IMRT, the mean dose of the heart decreased by 42%, the maximum dose of LAD decreased by 26.4%, and the mean dose of LAD decreased by 47.0%. The mean dose of the left ventricle decreased by 54.1%, the volume (V<sub>20</sub>) of the left lung that received 20 Gy decreased by 22.8%, the volume (V<sub>10</sub>) of the left lung that received 10 Gy decreased by 19.8%, the volume (V<sub>5</sub>) of the left lung that received 5 Gy decreased by 15.7%, and the mean dose of the left lung decreased by 23.3%. Using PERSBRA with IMRT greatly decreases the dose to organs at risk (left lung, heart, left ventricle, and LAD). This study found that PERSBRA with IMRT can achieve results similar to deep inspiration breath-hold radiotherapy (DIBH) in terms of reducing the heart radiation dose and the risk of developing heart disease in patients with left breast cancer who cannot undergo DIBH. |
| first_indexed | 2024-03-09T23:29:26Z |
| format | Article |
| id | doaj.art-9e48fd2575094fe897bbb3c0e14f15ae |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:29:26Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-9e48fd2575094fe897bbb3c0e14f15ae2023-11-23T17:11:58ZengMDPI AGJournal of Personalized Medicine2075-44262022-08-01129136810.3390/jpm12091368Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRTChiu-Ping Chen0Tung-Ho Chen1Jeng-Fong Chiou2Yi-Ju Chen3Chia-Chun Kuo4Kuo-Hsiung Tseng5Meng-Yun Chung6Chun-You Chen7Jeng-You Wu8Long-Sheng Lu9Shih-Ming Hsu10Department of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, TaiwanDepartment of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Electrical Engineering, National Taipei University of Technology, Taipei 106, TaiwanDepartment of Electrical Engineering, National Taipei University of Technology, Taipei 106, TaiwanDepartment of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei 116, TaiwanDepartment of Radiation Oncology, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, TaiwanDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanThis study evaluated dose differences in normal organs at risk, such as the lungs, heart, left anterior descending artery (LAD), right coronary artery, left ventricle, and right breast under personalized breast holder (PERSBRA), when using intensity-modulated radiation therapy (IMRT). This study evaluated the radiation protection offered by PERSBRA in left breast cancer radiation therapy. Here, we retrospectively collected data from 24 patients with left breast cancer who underwent breast-conserving surgery as well as IMRT radiotherapy. We compared the dose differences in target coverage and organs at risk with and without PERSBRA. For target coverage, tumor prescribed dose 95% coverage, conformity index, and homogeneity index were evaluated. For organs at risk, we compared the mean heart dose, mean left ventricle dose, LAD maximum and mean dose, mean left lung receiving 20 Gy, 10 Gy, and 5 Gy of left lung volume, maximum and mean coronary artery of the right, maximum of right breast, and mean dose. Good target coverage was achieved with and without PERSBRA. When PERSBRA was used with IMRT, the mean dose of the heart decreased by 42%, the maximum dose of LAD decreased by 26.4%, and the mean dose of LAD decreased by 47.0%. The mean dose of the left ventricle decreased by 54.1%, the volume (V<sub>20</sub>) of the left lung that received 20 Gy decreased by 22.8%, the volume (V<sub>10</sub>) of the left lung that received 10 Gy decreased by 19.8%, the volume (V<sub>5</sub>) of the left lung that received 5 Gy decreased by 15.7%, and the mean dose of the left lung decreased by 23.3%. Using PERSBRA with IMRT greatly decreases the dose to organs at risk (left lung, heart, left ventricle, and LAD). This study found that PERSBRA with IMRT can achieve results similar to deep inspiration breath-hold radiotherapy (DIBH) in terms of reducing the heart radiation dose and the risk of developing heart disease in patients with left breast cancer who cannot undergo DIBH.https://www.mdpi.com/2075-4426/12/9/1368breast cancerpersonalized breast holderorgans at riskintensity-modulated radiation therapy |
| spellingShingle | Chiu-Ping Chen Tung-Ho Chen Jeng-Fong Chiou Yi-Ju Chen Chia-Chun Kuo Kuo-Hsiung Tseng Meng-Yun Chung Chun-You Chen Jeng-You Wu Long-Sheng Lu Shih-Ming Hsu Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT Journal of Personalized Medicine breast cancer personalized breast holder organs at risk intensity-modulated radiation therapy |
| title | Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT |
| title_full | Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT |
| title_fullStr | Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT |
| title_full_unstemmed | Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT |
| title_short | Retrospective Analysis for Dose Reduction to Organs at Risk with New Personalized Breast Holder (PERSBRA) in Left Breast IMRT |
| title_sort | retrospective analysis for dose reduction to organs at risk with new personalized breast holder persbra in left breast imrt |
| topic | breast cancer personalized breast holder organs at risk intensity-modulated radiation therapy |
| url | https://www.mdpi.com/2075-4426/12/9/1368 |
| work_keys_str_mv | AT chiupingchen retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT tunghochen retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT jengfongchiou retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT yijuchen retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT chiachunkuo retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT kuohsiungtseng retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT mengyunchung retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT chunyouchen retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT jengyouwu retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT longshenglu retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt AT shihminghsu retrospectiveanalysisfordosereductiontoorgansatriskwithnewpersonalizedbreastholderpersbrainleftbreastimrt |