Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm
Inflammatory cytokines are elevated in patients with myeloproliferative neoplasms (MPN). Here the authors show that the JAK2-V617F mutation is associated with increased expression of IL-1 in MPN patients and that loss of IL-1β in JAK2-V617F mutant hematopoietic cells reduces MPN symptoms and myelofi...
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Bibliographic Details
| Main Authors: |
Shivam Rai,
Elodie Grockowiak,
Nils Hansen,
Damien Luque Paz,
Cedric B. Stoll,
Hui Hao-Shen,
Gabriele Mild-Schneider,
Stefan Dirnhofer,
Christopher J. Farady,
Simón Méndez-Ferrer,
Radek C. Skoda |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32927-4
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