Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia
Background: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy. Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia accor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2022;volume=28;issue=6;spage=434;epage=440;aulast=Ebik |
| _version_ | 1798006184525955072 |
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| author | Berat Ebik Nihat Aslan Nazım Ekin Ferhat Bacaksiz Medeni Arpa Salim Neselioglu Ozcan Erel Feyzullah Ucmak |
| author_facet | Berat Ebik Nihat Aslan Nazım Ekin Ferhat Bacaksiz Medeni Arpa Salim Neselioglu Ozcan Erel Feyzullah Ucmak |
| author_sort | Berat Ebik |
| collection | DOAJ |
| description | Background: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy.
Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. First, blood samples were drawn from patients to determine their serum thiol and disulphide levels. Endoscopic biopsy was performed on all patients and the biopsy specimens obtained were examined pathologically. Patients positive for H. pylori were administered eradication therapy. Blood samples were drawn from these patients for the second time, and their serum thiol and disulphide levels were measured. The thiol–disulfide levels of the patients who were successful in H. pylori eradication treatment, with those who were not, were compared before and after the treatment.
Results: The mean plasma disulphide level decreased significantly from 14.0 ± 6.6 to 10.9 ± 5.9 μmol/L in H. pylori-positive patients that responded to the H. pylori eradication treatment (P = 0.033). On the other hand, there was an insignificant increase in the mean serum thiol level (341.4 ± 30.5 vs. 342.6 ± 29.8 μmol/L; P = 0.273) and an insignificant decrease in the mean serum disulphide level (15.2 ± 2.5 vs. 14.8 ± 2.3 μmol/L; P = 0.163) in H. pylori-positive patients that did not respond to the H. pylori eradication treatment.
Conclusion: The inflammation caused by H. pylori shifted the thiol–disulphide equilibrium in the cell redox system towards the direction of disulphide. The study findings suggest that the restoration of the said hemostatic balance with eradication therapy relieved the organism from oxidative stress. |
| first_indexed | 2024-04-11T12:50:51Z |
| format | Article |
| id | doaj.art-9e4c593778414a3fb63f3c170d193450 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-04-11T12:50:51Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-9e4c593778414a3fb63f3c170d1934502022-12-22T04:23:12ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492022-01-0128643444010.4103/sjg.sjg_114_22Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsiaBerat EbikNihat AslanNazım EkinFerhat BacaksizMedeni ArpaSalim NeseliogluOzcan ErelFeyzullah UcmakBackground: To investigage the thiol and disulphide levels in Helicobacter pylori-positive patients with non-ulcer dyspepsia and investigate the change in these levels with eradication therapy. Methods: This is a prospective observational study. A total of 320 patients diagnosed with dyspepsia according to Rome IV criteria were included in the study. First, blood samples were drawn from patients to determine their serum thiol and disulphide levels. Endoscopic biopsy was performed on all patients and the biopsy specimens obtained were examined pathologically. Patients positive for H. pylori were administered eradication therapy. Blood samples were drawn from these patients for the second time, and their serum thiol and disulphide levels were measured. The thiol–disulfide levels of the patients who were successful in H. pylori eradication treatment, with those who were not, were compared before and after the treatment. Results: The mean plasma disulphide level decreased significantly from 14.0 ± 6.6 to 10.9 ± 5.9 μmol/L in H. pylori-positive patients that responded to the H. pylori eradication treatment (P = 0.033). On the other hand, there was an insignificant increase in the mean serum thiol level (341.4 ± 30.5 vs. 342.6 ± 29.8 μmol/L; P = 0.273) and an insignificant decrease in the mean serum disulphide level (15.2 ± 2.5 vs. 14.8 ± 2.3 μmol/L; P = 0.163) in H. pylori-positive patients that did not respond to the H. pylori eradication treatment. Conclusion: The inflammation caused by H. pylori shifted the thiol–disulphide equilibrium in the cell redox system towards the direction of disulphide. The study findings suggest that the restoration of the said hemostatic balance with eradication therapy relieved the organism from oxidative stress.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2022;volume=28;issue=6;spage=434;epage=440;aulast=Ebikeradicationhelicobacter pylorioxidative stressthiol-disulphide hemostasis |
| spellingShingle | Berat Ebik Nihat Aslan Nazım Ekin Ferhat Bacaksiz Medeni Arpa Salim Neselioglu Ozcan Erel Feyzullah Ucmak Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia The Saudi Journal of Gastroenterology eradication helicobacter pylori oxidative stress thiol-disulphide hemostasis |
| title | Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia |
| title_full | Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia |
| title_fullStr | Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia |
| title_full_unstemmed | Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia |
| title_short | Oxidative stress and the importance of H. pylori eradication in patients with functional dyspepsia |
| title_sort | oxidative stress and the importance of h pylori eradication in patients with functional dyspepsia |
| topic | eradication helicobacter pylori oxidative stress thiol-disulphide hemostasis |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2022;volume=28;issue=6;spage=434;epage=440;aulast=Ebik |
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