Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors. During development, CHD7 controls several differentiation programs, mainly by acting on neural progenitors and neural crest (NC) cells. Thus, its role...
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| Format: | Article |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.638674/full |
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| author | Antonella Lettieri Antonella Lettieri Roberto Oleari Alyssa J. J. Paganoni Cristina Gervasini Cristina Gervasini Valentina Massa Valentina Massa Alessandro Fantin Anna Cariboni |
| author_facet | Antonella Lettieri Antonella Lettieri Roberto Oleari Alyssa J. J. Paganoni Cristina Gervasini Cristina Gervasini Valentina Massa Valentina Massa Alessandro Fantin Anna Cariboni |
| author_sort | Antonella Lettieri |
| collection | DOAJ |
| description | CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors. During development, CHD7 controls several differentiation programs, mainly by acting on neural progenitors and neural crest (NC) cells. Thus, its roles range from the central nervous system to the peripheral nervous system and the organs colonized by NC cells, including the heart. Accordingly, mutated CHD7 is linked to CHARGE syndrome, which is characterized by several neuronal dysfunctions and by malformations of NC-derived/populated organs. Altered CHD7 has also been associated with different neoplastic transformations. Interestingly, recent evidence revealed that semaphorins, a class of molecules involved in developmental and pathological processes similar to those controlled by CHD7, are regulated by CHD7 in a context-specific manner. In this article, we will review the recent insights that support the existence of genetic interactions between these pathways, both during developmental processes and cancer progression. |
| first_indexed | 2024-12-22T19:37:56Z |
| format | Article |
| id | doaj.art-9e4d4856d4844538aec1c16a4a6c8d1d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T19:37:56Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9e4d4856d4844538aec1c16a4a6c8d1d2022-12-21T18:14:55ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-04-01910.3389/fcell.2021.638674638674Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and CancerAntonella Lettieri0Antonella Lettieri1Roberto Oleari2Alyssa J. J. Paganoni3Cristina Gervasini4Cristina Gervasini5Valentina Massa6Valentina Massa7Alessandro Fantin8Anna Cariboni9CRC Aldo Ravelli for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyCRC Aldo Ravelli for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyCRC Aldo Ravelli for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, Milan, ItalyDepartment of Biosciences, Università degli Studi di Milano, Milan, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, ItalyCHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors. During development, CHD7 controls several differentiation programs, mainly by acting on neural progenitors and neural crest (NC) cells. Thus, its roles range from the central nervous system to the peripheral nervous system and the organs colonized by NC cells, including the heart. Accordingly, mutated CHD7 is linked to CHARGE syndrome, which is characterized by several neuronal dysfunctions and by malformations of NC-derived/populated organs. Altered CHD7 has also been associated with different neoplastic transformations. Interestingly, recent evidence revealed that semaphorins, a class of molecules involved in developmental and pathological processes similar to those controlled by CHD7, are regulated by CHD7 in a context-specific manner. In this article, we will review the recent insights that support the existence of genetic interactions between these pathways, both during developmental processes and cancer progression.https://www.frontiersin.org/articles/10.3389/fcell.2021.638674/fullCHD7chromatin remodelersemaphorinsdevelopmentcancer |
| spellingShingle | Antonella Lettieri Antonella Lettieri Roberto Oleari Alyssa J. J. Paganoni Cristina Gervasini Cristina Gervasini Valentina Massa Valentina Massa Alessandro Fantin Anna Cariboni Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer Frontiers in Cell and Developmental Biology CHD7 chromatin remodeler semaphorins development cancer |
| title | Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer |
| title_full | Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer |
| title_fullStr | Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer |
| title_full_unstemmed | Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer |
| title_short | Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer |
| title_sort | semaphorin regulation by the chromatin remodeler chd7 an emerging genetic interaction shaping neural cells and neural crest in development and cancer |
| topic | CHD7 chromatin remodeler semaphorins development cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.638674/full |
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